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Nanomaterials 2015, 5(4), 1853-1879; doi:10.3390/nano5041853

Gold Nanotheranostics: Proof-of-Concept or Clinical Tool?

UCIBIO, Department of Life Sciences, Faculdade de Ciências e Tecnologia, Campus Caparica, 2829-516 Caparica, Portugal
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Academic Editor: Subramanian Tamil Selvan
Received: 22 August 2015 / Revised: 4 October 2015 / Accepted: 27 October 2015 / Published: 3 November 2015
(This article belongs to the Special Issue Nanoparticles in Theranostics)
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Abstract

Nanoparticles have been making their way in biomedical applications and personalized medicine, allowing for the coupling of diagnostics and therapeutics into a single nanomaterial—nanotheranostics. Gold nanoparticles, in particular, have unique features that make them excellent nanomaterials for theranostics, enabling the integration of targeting, imaging and therapeutics in a single platform, with proven applicability in the management of heterogeneous diseases, such as cancer. In this review, we focus on gold nanoparticle-based theranostics at the lab bench, through pre-clinical and clinical stages. With few products facing clinical trials, much remains to be done to effectively assess the real benefits of nanotheranostics at the clinical level. Hence, we also discuss the efforts currently being made to translate nanotheranostics into the market, as well as their commercial impact. View Full-Text
Keywords: nanotheranostics; diagnostics; targeted therapy; cancer; gold nanoparticles; precision medicine; theranostics nanotheranostics; diagnostics; targeted therapy; cancer; gold nanoparticles; precision medicine; theranostics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Pedrosa, P.; Vinhas, R.; Fernandes, A.; Baptista, P.V. Gold Nanotheranostics: Proof-of-Concept or Clinical Tool? Nanomaterials 2015, 5, 1853-1879.

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