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Frontiers in Nucleic Acid Nanotechnology
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Nanomaterials 2015, 5(2), 804-813;

Phosphorothioate DNA Stabilized Fluorescent Gold and Silver Nanoclusters

Department of Chemistry, Waterloo Institute for Nanotechnology, Waterloo, ON N2L 3G1, Canada
Author to whom correspondence should be addressed.
Academic Editor: Stephen Ralph
Received: 30 March 2015 / Accepted: 7 May 2015 / Published: 19 May 2015
(This article belongs to the Special Issue Frontiers in Nucleic Acid Nanotechnology)
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Unmodified single-stranded DNA has recently gained popularity for the templated synthesis of fluorescent noble metal nanoclusters (NCs). Bright, stable, and biocompatible clusters have been developed primarily through optimization of DNA sequence. However, DNA backbone modifications have not yet been investigated. In this work, phosphorothioate (PS) DNAs are evaluated in the synthesis of Au and Ag nanoclusters, and are employed to successfully template a novel emitter using T15 DNA at neutral pH. Mechanistic studies indicate a distinct UV-dependent formation mechanism that does not occur through the previously reported thymine N3. The positions of PS substitution have been optimized. This is the first reported use of a T15 template at physiological pH for AgNCs. View Full-Text
Keywords: DNA; phosphorothioate; luminescence; nanoclusters DNA; phosphorothioate; luminescence; nanoclusters

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Weadick, D.S.; Liu, J. Phosphorothioate DNA Stabilized Fluorescent Gold and Silver Nanoclusters. Nanomaterials 2015, 5, 804-813.

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