Next Article in Journal
Specialized Living Wound Dressing Based on the Self-Assembly Approach of Tissue Engineering
Next Article in Special Issue
The Use of Some Clay Minerals as Natural Resources for Drug Carrier Applications
Previous Article in Journal
Fabrication and Multiscale Structural Properties of Interconnected Porous Biomaterial for Tissue Engineering by Freeze Isostatic Pressure (FIP)
Article Menu
Issue 3 (September) cover image

Export Article

Open AccessArticle
J. Funct. Biomater. 2018, 9(3), 52; https://doi.org/10.3390/jfb9030052

Formulation and Evaluation of Silymarin-Loaded Chitosan-Montmorilloite Microbeads for the Potential Treatment of Gastric Ulcers

1
Department of Pharmaceutics, Chitkara College of Pharmacy, Chitkara University, Patiala 140401, India
2
University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160101, India
*
Author to whom correspondence should be addressed.
Received: 30 July 2018 / Revised: 28 August 2018 / Accepted: 4 September 2018 / Published: 10 September 2018
(This article belongs to the Special Issue Clay-Based Biomaterials: From Synthesis to Applications)
Full-Text   |   PDF [3100 KB, uploaded 19 September 2018]   |  

Abstract

Silymarin-loaded mucoadhesive microbeads of Chitosan-MMT were developed using the ionotropic gelation technique. Characterization of the microbeads was performed by DSC, XRD, SEM, and FTIR techniques. In vitro mucoadhesion and drug release studies; gastroprotective studies including the measurement of ulcerative index; the determination of gastric wall mucus; and the determination of percentage protection, biochemical, and histopathological studies were also performed. Microbeads batches were evaluated for particle size (120–140 µm), actual drug content, (49.36–58.18%) and entrapment efficiency (72.52–92.39%).Biochemical estimation of myeloperoxidase was found to be 0.10–0.75 µmoles/g/tissue. Significant reduction in the ulcerative index showed the gastroprotective effect of the formulation. Silymarin-loaded beads of Chitosan-MMT were found to exhibit good mucoadhesion and efficient release of the drug, and were found to be a promising drug carrier system for the treatment of gastric ulcers. View Full-Text
Keywords: Microbeads; silymarin; chitosan; montmorillonite; gastric ulcers Microbeads; silymarin; chitosan; montmorillonite; gastric ulcers
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Sharma, A.; Puri, V.; Kakkar, V.; Singh, I. Formulation and Evaluation of Silymarin-Loaded Chitosan-Montmorilloite Microbeads for the Potential Treatment of Gastric Ulcers. J. Funct. Biomater. 2018, 9, 52.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Funct. Biomater. EISSN 2079-4983 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top