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J. Funct. Biomater. 2017, 8(3), 39; doi:10.3390/jfb8030039

Evaluation of Polyethylene Glycol Diacrylate-Polycaprolactone Scaffolds for Tissue Engineering Applications

Department of Biology, University of Central Oklahoma, Edmond, OK 73034, USA
Department of Engineering & Physics, University of Central Oklahoma, Edmond, OK 73034, USA
Author to whom correspondence should be addressed.
Received: 1 July 2017 / Revised: 26 August 2017 / Accepted: 2 September 2017 / Published: 5 September 2017
(This article belongs to the Special Issue Biodegradable Scaffolds)
View Full-Text   |   Download PDF [3238 KB, uploaded 5 September 2017]   |  


Polyethylene Glycol Diacrylate (PEGDA) tissue scaffolds having a thickness higher than 1 mm and without the presence of nutrient conduit networks were shown to have limited applications in tissue engineering due to the inability of cells to adhere and migrate within the scaffold. The PEGDA scaffold has been coated with polycaprolactone (PCL) electrospun nanofiber (ENF) membrane on both sides to overcome these limitations, thereby creating a functional PEGDA-PCL scaffold. This study examined the physical, mechanical, and biological properties of the PEGDA and PEGDA-PCL scaffolds to determine the effect of PCL coating on PEGDA. The physical characterization of PEGDA-PCL samples demonstrated the effectiveness of combining PCL with a PEGDA scaffold to expand its applications in tissue engineering. This study also found a significant improvement of elasticity of PEGDA due to the addition of PCL layers. This study shows that PEGDA-PCL scaffolds absorb nutrients with time and can provide an ideal environment for the survival of cells. Furthermore, cell viability tests indicate that the cell adhered, proliferated, and migrated in the PEGDA-PCL scaffold. Therefore, PCL ENF coating has a positive influence on PEGDA scaffold. View Full-Text
Keywords: polyethylene glycol diacrylate; polycaprolactone; scaffold; electrospun; nanofiber polyethylene glycol diacrylate; polycaprolactone; scaffold; electrospun; nanofiber

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kotturi, H.; Abuabed, A.; Zafar, H.; Sawyer, E.; Pallipparambil, B.; Jamadagni, H.; Khandaker, M. Evaluation of Polyethylene Glycol Diacrylate-Polycaprolactone Scaffolds for Tissue Engineering Applications. J. Funct. Biomater. 2017, 8, 39.

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J. Funct. Biomater. EISSN 2079-4983 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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