Dental Composite Formulation Design with Bioactivity on Protein Adsorption Combined with Crack-Healing Capability
AbstractFracture and secondary caries are the primary reasons for the failure of dental restorations. To face this omnipresent problem, we report the formulation design and synthesis of a protein-resistant dental composite composed of 2-methacryloyloxyethyl phosphorylcholine (MPC) that also can self-repair damage and recover the load-bearing capability via microencapsulated triethylene glycol dimethacrylate (TEGDMA) and N,N-dihydroxy ethyl-p-toluidine (DHEPT). The bioactivity of the resulting MPC-microencapsulated TEGDMA-DHEPT was evaluated on protein adsorption through early bacterial attachment. Its mechanical properties were also investigated, including self-healing assessment. Microcapsules of poly (urea-formaldehyde) (PUF) were synthesized by incorporating a TEGDMA-DHEPT healing liquid. A set of composites that contained 7.5% of MPC, 10% of microcapsules, and without MPC/microcapsules were also prepared as controls. The two distinct characteristics of strong protein repellency and load-bearing recovery were achieved by the combined strategies. The novel dual composite with a combination of protein-repellent MPC and PUF microcapsules for restoring microcracks is a promising strategy for dental restorations to address the two main challenges of fracture and secondary caries. The new dual composite formulation design has the potential to improve the longevity of dental restorations significantly. View Full-Text
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Chen, C.; Wu, J.; Weir, M.D.; Wang, L.; Zhou, X.; Xu, H.H.K.; Melo, M.A.S. Dental Composite Formulation Design with Bioactivity on Protein Adsorption Combined with Crack-Healing Capability. J. Funct. Biomater. 2017, 8, 40.
Chen C, Wu J, Weir MD, Wang L, Zhou X, Xu HHK, Melo MAS. Dental Composite Formulation Design with Bioactivity on Protein Adsorption Combined with Crack-Healing Capability. Journal of Functional Biomaterials. 2017; 8(3):40.Chicago/Turabian Style
Chen, Chen; Wu, Junling; Weir, Michael D.; Wang, Lin; Zhou, Xuedong; Xu, Hockin H.K.; Melo, Mary A.S. 2017. "Dental Composite Formulation Design with Bioactivity on Protein Adsorption Combined with Crack-Healing Capability." J. Funct. Biomater. 8, no. 3: 40.