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J. Funct. Biomater. 2017, 8(3), 40; https://doi.org/10.3390/jfb8030040

Dental Composite Formulation Design with Bioactivity on Protein Adsorption Combined with Crack-Healing Capability

1
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
2
Department of Prosthodontics, Endodontics and Operative Dentistry, University of Maryland School of Dentistry, Baltimore, MD 21201, USA
3
Shandong Provincial Key Laboratory of Oral Biomedicine, Jinan 250012, China
4
VIP Integrated Department, Stomatological Hospital of Jilin University, Changchun 130011, China
5
Center for Stem Cell Biology & Regenerative Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
6
Department of Mechanical Engineering, University of Maryland, Baltimore County, MD 21250, USA
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 9 August 2017 / Revised: 28 August 2017 / Accepted: 30 August 2017 / Published: 7 September 2017
(This article belongs to the Special Issue Journal of Functional Biomaterials: Feature Papers 2016)
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Abstract

Fracture and secondary caries are the primary reasons for the failure of dental restorations. To face this omnipresent problem, we report the formulation design and synthesis of a protein-resistant dental composite composed of 2-methacryloyloxyethyl phosphorylcholine (MPC) that also can self-repair damage and recover the load-bearing capability via microencapsulated triethylene glycol dimethacrylate (TEGDMA) and N,N-dihydroxy ethyl-p-toluidine (DHEPT). The bioactivity of the resulting MPC-microencapsulated TEGDMA-DHEPT was evaluated on protein adsorption through early bacterial attachment. Its mechanical properties were also investigated, including self-healing assessment. Microcapsules of poly (urea-formaldehyde) (PUF) were synthesized by incorporating a TEGDMA-DHEPT healing liquid. A set of composites that contained 7.5% of MPC, 10% of microcapsules, and without MPC/microcapsules were also prepared as controls. The two distinct characteristics of strong protein repellency and load-bearing recovery were achieved by the combined strategies. The novel dual composite with a combination of protein-repellent MPC and PUF microcapsules for restoring microcracks is a promising strategy for dental restorations to address the two main challenges of fracture and secondary caries. The new dual composite formulation design has the potential to improve the longevity of dental restorations significantly. View Full-Text
Keywords: self-healing; microcapsules; mechanical property; protein repellent; dental composite self-healing; microcapsules; mechanical property; protein repellent; dental composite
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Chen, C.; Wu, J.; Weir, M.D.; Wang, L.; Zhou, X.; Xu, H.H.K.; Melo, M.A.S. Dental Composite Formulation Design with Bioactivity on Protein Adsorption Combined with Crack-Healing Capability. J. Funct. Biomater. 2017, 8, 40.

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