Next Article in Journal / Special Issue
Advances in Skin Substitutes—Potential of Tissue Engineered Skin for Facilitating Anti-Fibrotic Healing
Previous Article in Journal
Medical Textiles as Vascular Implants and Their Success to Mimic Natural Arteries
Previous Article in Special Issue
Characterization of a Pre-Clinical Mini-Pig Model of Scaphoid Non-Union
Article Menu

Export Article

Open AccessReview
J. Funct. Biomater. 2015, 6(3), 526-546; doi:10.3390/jfb6030526

Magnetically Targeted Stem Cell Delivery for Regenerative Medicine

1
Joint Department of Biomedical Engineering, UNC-Chapel Hill & NC State University, NC 27606, USA
2
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA
3
Division of Cardiothoracic Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Francesco Puoci
Received: 23 April 2015 / Revised: 11 June 2015 / Accepted: 23 June 2015 / Published: 30 June 2015
(This article belongs to the Special Issue Feature Papers)
View Full-Text   |   Download PDF [742 KB, uploaded 30 June 2015]   |  

Abstract

Stem cells play a special role in the body as agents of self-renewal and auto-reparation for tissues and organs. Stem cell therapies represent a promising alternative strategy to regenerate damaged tissue when natural repairing and conventional pharmacological intervention fail to do so. A fundamental impediment for the evolution of stem cell therapies has been the difficulty of effectively targeting administered stem cells to the disease foci. Biocompatible magnetically responsive nanoparticles are being utilized for the targeted delivery of stem cells in order to enhance their retention in the desired treatment site. This noninvasive treatment-localization strategy has shown promising results and has the potential to mitigate the problem of poor long-term stem cell engraftment in a number of organ systems post-delivery. In addition, these same nanoparticles can be used to track and monitor the cells in vivo, using magnetic resonance imaging. In the present review we underline the principles of magnetic targeting for stem cell delivery, with a look at the logic behind magnetic nanoparticle systems, their manufacturing and design variants, and their applications in various pathological models. View Full-Text
Keywords: SPION; magnetic targeting; stem cell; magnetic nanoparticle; regenerative medicine SPION; magnetic targeting; stem cell; magnetic nanoparticle; regenerative medicine
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Cores, J.; Caranasos, T.G.; Cheng, K. Magnetically Targeted Stem Cell Delivery for Regenerative Medicine. J. Funct. Biomater. 2015, 6, 526-546.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Funct. Biomater. EISSN 2079-4983 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top