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J. Funct. Biomater. 2015, 6(2), 407-421; doi:10.3390/jfb6020407

Characterization of a Pre-Clinical Mini-Pig Model of Scaphoid Non-Union

1
Bone Engineering Labs, Research Institute-McGill University Health Centre, Montreal General Hospital, 1650 Cedar Ave, Montreal, Quebec H3G 1A4, Canada
2
Experimental Surgery, Faculty of Medicine, Montreal General Hospital, 1650 Cedar Ave, Montreal, Quebec H3G 1A4, Canada
3
Experimental Medicine, Faculty of Medicine, McGill University, Room 101, 1110 Pins Avenue West, Montreal, Quebec H3A 1A3, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Francesco Puoci
Received: 25 May 2015 / Accepted: 9 June 2015 / Published: 16 June 2015
(This article belongs to the Special Issue Feature Papers)
View Full-Text   |   Download PDF [5372 KB, uploaded 16 June 2015]   |  

Abstract

A fractured scaphoid is a common disabling injury that is frequently complicated by non-union. The treatment of non-union remains challenging because of the scaphoid’s small size and delicate blood supply. Large animal models are the most reliable method to evaluate the efficacy of new treatment modalities before their translation into clinical practice. The goal of this study was to model a human scaphoid fracture complicated by non-union in Yucatan mini-pigs. Imaging and perfusion studies were used to confirm that the anatomy and blood supply of the radiocarpal bone in mini-pigs were similar to the human scaphoid. A 3 mm osteotomy of the radiocarpal bone was generated and treated with immediate fixation or filled with a dense collagen gel followed by delayed fixation. Bone healing was assessed using quantitative micro computed tomography and histology. With immediate fixation, the osteotomy site was filled with new bone across its whole length resulting in complete bridging. The dense collagen gel, previously shown to impede neo-vascularization, followed by delayed fixation resulted in impaired bridging with less bone of lower quality. This model is an appropriate, easily reproducible model for the evaluation of novel approaches for the repair of human scaphoid fractures. View Full-Text
Keywords: dense collagen gel; pre-clinical model; headless titanium screw; quantitative micro CT dense collagen gel; pre-clinical model; headless titanium screw; quantitative micro CT
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Behrends, D.A.; Khendek, L.; Gao, C.; Zayed, N.; Henderson, J.E.; Martineau, P.A. Characterization of a Pre-Clinical Mini-Pig Model of Scaphoid Non-Union. J. Funct. Biomater. 2015, 6, 407-421.

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J. Funct. Biomater. EISSN 2079-4983 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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