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Ciprofloxacin-Collagen Conjugate in the Wound Healing Treatment
Department of Pharmaceutical Sciences, University of Calabria, Edificio Polifunzionale, Arcavacata di Rende (CS) 87036, Italy
Principium Europe, Via Como 45, Solaro (MI) 20020, Italy
Department of Thoracic Surgery, Policlinico Universitario Germaneto-Fondazione Tommaso Campanella, Campus Universitario “Salvatore Venuta” Viale Europa, Località Germaneto 88100, Italy
* Author to whom correspondence should be addressed.
Received: 22 March 2012; in revised form: 7 May 2012 / Accepted: 7 May 2012 / Published: 15 May 2012
Abstract: The synthesis of a novel functional biomaterial for wound healing treatment was carried out by adopting a free-radical grafting procedure in aqueous media. With this aim, ciprofloxacin (CFX) was covalently incorporated into collagen (T1C) chains employing an ascorbic acid/hydrogen peroxide redox pair as biocompatible initiator system. The covalent insertion of CFX in the polymeric chains was confirmed by FT-IR and UV analyses, while an antibacterial assay demonstrated the activity of the synthesized conjugate against Staphylococcus aureus and Escherichia coli, microorganisms that commonly infect wounds. A catechin blended conjugate was also tested in order to evaluate the ability to influence fibroblast cell growth. The observed antibacterial activity and stimulation of fibroblast growth support the applicability of CFX-T1C conjugate in wound treatment encouraging the healing process.
Keywords: protein; ciprofloxacin; quinolones; biomedical application; antibiotic; antimicrobial; infection; wound healing; fibroblast proliferation
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Puoci, F.; Piangiolino, C.; Givigliano, F.; Parisi, O.I.; Cassano, R.; Trombino, S.; Curcio, M.; Iemma, F.; Cirillo, G.; Spizzirri, U.G.; Restuccia, D.; Muzzalupo, R.; Picci, N. Ciprofloxacin-Collagen Conjugate in the Wound Healing Treatment. J. Funct. Biomater. 2012, 3, 361-371.
Puoci F, Piangiolino C, Givigliano F, Parisi OI, Cassano R, Trombino S, Curcio M, Iemma F, Cirillo G, Spizzirri UG, Restuccia D, Muzzalupo R, Picci N. Ciprofloxacin-Collagen Conjugate in the Wound Healing Treatment. Journal of Functional Biomaterials. 2012; 3(2):361-371.
Puoci, Francesco; Piangiolino, Cristiana; Givigliano, Francesco; Parisi, Ortensia Ilaria; Cassano, Roberta; Trombino, Sonia; Curcio, Manuela; Iemma, Francesca; Cirillo, Giuseppe; Spizzirri, Umile Gianfranco; Restuccia, Donatella; Muzzalupo, Rita; Picci, Nevio. 2012. "Ciprofloxacin-Collagen Conjugate in the Wound Healing Treatment." J. Funct. Biomater. 3, no. 2: 361-371.