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J. Funct. Biomater. 2012, 3(2), 361-371; doi:10.3390/jfb3020361

Ciprofloxacin-Collagen Conjugate in the Wound Healing Treatment

1
Department of Pharmaceutical Sciences, University of Calabria, Edificio Polifunzionale, Arcavacata di Rende (CS) 87036, Italy
2
Principium Europe, Via Como 45, Solaro (MI) 20020, Italy
3
Department of Thoracic Surgery, Policlinico Universitario Germaneto-Fondazione Tommaso Campanella, Campus Universitario “Salvatore Venuta” Viale Europa, Località Germaneto 88100, Italy
*
Author to whom correspondence should be addressed.
Received: 22 March 2012 / Revised: 7 May 2012 / Accepted: 7 May 2012 / Published: 15 May 2012
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Abstract

The synthesis of a novel functional biomaterial for wound healing treatment was carried out by adopting a free-radical grafting procedure in aqueous media. With this aim, ciprofloxacin (CFX) was covalently incorporated into collagen (T1C) chains employing an ascorbic acid/hydrogen peroxide redox pair as biocompatible initiator system. The covalent insertion of CFX in the polymeric chains was confirmed by FT-IR and UV analyses, while an antibacterial assay demonstrated the activity of the synthesized conjugate against Staphylococcus aureus and Escherichia coli, microorganisms that commonly infect wounds. A catechin blended conjugate was also tested in order to evaluate the ability to influence fibroblast cell growth. The observed antibacterial activity and stimulation of fibroblast growth support the applicability of CFX-T1C conjugate in wound treatment encouraging the healing process. View Full-Text
Keywords: protein; ciprofloxacin; quinolones; biomedical application; antibiotic; antimicrobial; infection; wound healing; fibroblast proliferation protein; ciprofloxacin; quinolones; biomedical application; antibiotic; antimicrobial; infection; wound healing; fibroblast proliferation
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MDPI and ACS Style

Puoci, F.; Piangiolino, C.; Givigliano, F.; Parisi, O.I.; Cassano, R.; Trombino, S.; Curcio, M.; Iemma, F.; Cirillo, G.; Spizzirri, U.G.; Restuccia, D.; Muzzalupo, R.; Picci, N. Ciprofloxacin-Collagen Conjugate in the Wound Healing Treatment. J. Funct. Biomater. 2012, 3, 361-371.

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J. Funct. Biomater. EISSN 2079-4983 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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