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J. Funct. Biomater. 2011, 2(1), 1-17; doi:10.3390/jfb2010001
Article

Poly(2-hydroxyethyl methacrylate)-quercetin Conjugate as Biomaterial in Ophthalmology: An “ab initio” Study

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Received: 17 December 2010; in revised form: 13 January 2011 / Accepted: 26 January 2011 / Published: 27 January 2011
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Abstract: A novel polymeric material with antioxidant properties and suitable for ophthalmic application was synthesized by free radical grafting reaction between 2-hydroxyethyl methacrylate and quercetin. The presence of quercetin in the polymeric chain was confirmed by FT-IR and UV-Vis analyses, while an estimation of the amount of quercetin bound per gram of polymer was obtained by the Folin-Ciocalteu assay. The conjugate shows high biocompatibility (HET-CAM assay) and antioxidant and anti-inflammatory properties which were extensively investigated by specific in vitro tests.
Keywords: poly(2-hydroxyethyl methacrylate; quercetin; ocular tolerance; polymeric antioxidant poly(2-hydroxyethyl methacrylate; quercetin; ocular tolerance; polymeric antioxidant
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Curcio, M.; Cirillo, G.; Parisi, O.I.; Iemma, F.; Spizzirri, U.G.; Altimari, I.; Picci, N.; Puoci, F. Poly(2-hydroxyethyl methacrylate)-quercetin Conjugate as Biomaterial in Ophthalmology: An “ab initio” Study. J. Funct. Biomater. 2011, 2, 1-17.

AMA Style

Curcio M, Cirillo G, Parisi OI, Iemma F, Spizzirri UG, Altimari I, Picci N, Puoci F. Poly(2-hydroxyethyl methacrylate)-quercetin Conjugate as Biomaterial in Ophthalmology: An “ab initio” Study. Journal of Functional Biomaterials. 2011; 2(1):1-17.

Chicago/Turabian Style

Curcio, Manuela; Cirillo, Giuseppe; Parisi, Ortensia Ilaria; Iemma, Francesca; Spizzirri, Umile Gianfranco; Altimari, Ilaria; Picci, Nevio; Puoci, Francesco. 2011. "Poly(2-hydroxyethyl methacrylate)-quercetin Conjugate as Biomaterial in Ophthalmology: An “ab initio” Study." J. Funct. Biomater. 2, no. 1: 1-17.


J. Funct. Biomater. EISSN 2079-4983 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert