J. Funct. Biomater. 2011, 2(1), 1-17; doi:10.3390/jfb2010001
Article

Poly(2-hydroxyethyl methacrylate)-quercetin Conjugate as Biomaterial in Ophthalmology: An “ab initio” Study

Manuela Curcio 1,2 email, Giuseppe Cirillo 1,2,* email, Ortensia Ilaria Parisi 1,2 email, Francesca Iemma 1 email, Umile Gianfranco Spizzirri 1 email, Ilaria Altimari 1 email, Nevio Picci 1 email and Francesco Puoci 1 email
1 Dipartimento di Scienze Farmaceutiche, Università della Calabria, Edificio Polifunzionale, 87036 Arcavacata di Rende (CS), Italy 2 Macrofarm Srl, Università della Calabria, Edificio Polifunzionale, 87036 Arcavacata di Rende (CS), Italy
* Author to whom correspondence should be addressed.
Received: 17 December 2010; in revised form: 13 January 2011 / Accepted: 26 January 2011 / Published: 27 January 2011
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Abstract: A novel polymeric material with antioxidant properties and suitable for ophthalmic application was synthesized by free radical grafting reaction between 2-hydroxyethyl methacrylate and quercetin. The presence of quercetin in the polymeric chain was confirmed by FT-IR and UV-Vis analyses, while an estimation of the amount of quercetin bound per gram of polymer was obtained by the Folin-Ciocalteu assay. The conjugate shows high biocompatibility (HET-CAM assay) and antioxidant and anti-inflammatory properties which were extensively investigated by specific in vitro tests.
Keywords: poly(2-hydroxyethyl methacrylate; quercetin; ocular tolerance; polymeric antioxidant

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MDPI and ACS Style

Curcio, M.; Cirillo, G.; Parisi, O.I.; Iemma, F.; Spizzirri, U.G.; Altimari, I.; Picci, N.; Puoci, F. Poly(2-hydroxyethyl methacrylate)-quercetin Conjugate as Biomaterial in Ophthalmology: An “ab initio” Study. J. Funct. Biomater. 2011, 2, 1-17.

AMA Style

Curcio M, Cirillo G, Parisi OI, Iemma F, Spizzirri UG, Altimari I, Picci N, Puoci F. Poly(2-hydroxyethyl methacrylate)-quercetin Conjugate as Biomaterial in Ophthalmology: An “ab initio” Study. Journal of Functional Biomaterials. 2011; 2(1):1-17.

Chicago/Turabian Style

Curcio, Manuela; Cirillo, Giuseppe; Parisi, Ortensia Ilaria; Iemma, Francesca; Spizzirri, Umile Gianfranco; Altimari, Ilaria; Picci, Nevio; Puoci, Francesco. 2011. "Poly(2-hydroxyethyl methacrylate)-quercetin Conjugate as Biomaterial in Ophthalmology: An “ab initio” Study." J. Funct. Biomater. 2, no. 1: 1-17.

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