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J. Funct. Biomater. 2011, 2(1), 1-17; doi:10.3390/jfb2010001
Article

Poly(2-hydroxyethyl methacrylate)-quercetin Conjugate as Biomaterial in Ophthalmology: An “ab initio” Study

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1 Dipartimento di Scienze Farmaceutiche, Università della Calabria, Edificio Polifunzionale, 87036 Arcavacata di Rende (CS), Italy 2 Macrofarm Srl, Università della Calabria, Edificio Polifunzionale, 87036 Arcavacata di Rende (CS), Italy
* Author to whom correspondence should be addressed.
Received: 17 December 2010 / Revised: 13 January 2011 / Accepted: 26 January 2011 / Published: 27 January 2011
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Abstract

A novel polymeric material with antioxidant properties and suitable for ophthalmic application was synthesized by free radical grafting reaction between 2-hydroxyethyl methacrylate and quercetin. The presence of quercetin in the polymeric chain was confirmed by FT-IR and UV-Vis analyses, while an estimation of the amount of quercetin bound per gram of polymer was obtained by the Folin-Ciocalteu assay. The conjugate shows high biocompatibility (HET-CAM assay) and antioxidant and anti-inflammatory properties which were extensively investigated by specific in vitro tests.
Keywords: poly(2-hydroxyethyl methacrylate; quercetin; ocular tolerance; polymeric antioxidant poly(2-hydroxyethyl methacrylate; quercetin; ocular tolerance; polymeric antioxidant
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Curcio, M.; Cirillo, G.; Parisi, O.I.; Iemma, F.; Spizzirri, U.G.; Altimari, I.; Picci, N.; Puoci, F. Poly(2-hydroxyethyl methacrylate)-quercetin Conjugate as Biomaterial in Ophthalmology: An “ab initio” Study. J. Funct. Biomater. 2011, 2, 1-17.

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