Next Article in Journal
Numerical Modelling of Double-Steel Plate Composite Shear Walls
Next Article in Special Issue
Simplification of Reaction Networks, Confluence and Elementary Modes
Previous Article in Journal
Virtual Prototyping and Validation of Cpps within a New Software Framework
Previous Article in Special Issue
Towards a Multiscale Model of Acute HIV Infection
Article Menu

Export Article

Open AccessArticle
Computation 2017, 5(1), 11; doi:10.3390/computation5010011

Multiscale CT-Based Computational Modeling of Alveolar Gas Exchange during Artificial Lung Ventilation, Cluster (Biot) and Periodic (Cheyne-Stokes) Breathings and Bronchial Asthma Attack

1
Moscow Institute of Physics and Technology (State University), 9 Instituskii Lane, 141701 Dolgoprudny, Russia
2
Institute of Computer-Aided Design, RAS, 19/18 2nd Brestskaya St., 123056 Moscow, Russia
3
Institute of Numerical Mathematics, RAS, 8 Gubkina St., 119333 Moscow, Russia
4
Russian National Research Medical University named after N.I. Pirogov, 1 Ostrovitianov str., 117997 Moscow, Russia
*
Author to whom correspondence should be addressed.
Academic Editor: Rainer Breitling
Received: 31 October 2016 / Revised: 14 February 2017 / Accepted: 15 February 2017 / Published: 18 February 2017
(This article belongs to the Special Issue Multiscale and Hybrid Modeling of the Living Systems)
View Full-Text   |   Download PDF [2406 KB, uploaded 18 February 2017]   |  

Abstract

An airflow in the first four generations of the tracheobronchial tree was simulated by the 1D model of incompressible fluid flow through the network of the elastic tubes coupled with 0D models of lumped alveolar components, which aggregates parts of the alveolar volume and smaller airways, extended with convective transport model throughout the lung and alveolar components which were combined with the model of oxygen and carbon dioxide transport between the alveolar volume and the averaged blood compartment during pathological respiratory conditions. The novel features of this work are 1D reconstruction of the tracheobronchial tree structure on the basis of 3D segmentation of the computed tomography (CT) data; 1D−0D coupling of the models of 1D bronchial tube and 0D alveolar components; and the alveolar gas exchange model. The results of our simulations include mechanical ventilation, breathing patterns of severely ill patients with the cluster (Biot) and periodic (Cheyne-Stokes) respirations and bronchial asthma attack. The suitability of the proposed mathematical model was validated. Carbon dioxide elimination efficiency was analyzed in all these cases. In the future, these results might be integrated into research and practical studies aimed to design cyberbiological systems for remote real-time monitoring, classification, prediction of breathing patterns and alveolar gas exchange for patients with breathing problems. View Full-Text
Keywords: multiscale modeling; in silico; respiratory mechanics; alveolar gas exchange; mechanical ventilation; abnormal breathing patterns; bronchial asthma attack; normal (sinusoidal) breathing; cluster (Biot) breathing; periodic (Cheyne-Stokes) breathing multiscale modeling; in silico; respiratory mechanics; alveolar gas exchange; mechanical ventilation; abnormal breathing patterns; bronchial asthma attack; normal (sinusoidal) breathing; cluster (Biot) breathing; periodic (Cheyne-Stokes) breathing
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Golov, A.; Simakov, S.; Soe, Y.N.; Pryamonosov, R.; Mynbaev, O.; Kholodov, A. Multiscale CT-Based Computational Modeling of Alveolar Gas Exchange during Artificial Lung Ventilation, Cluster (Biot) and Periodic (Cheyne-Stokes) Breathings and Bronchial Asthma Attack. Computation 2017, 5, 11.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Computation EISSN 2079-3197 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top