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J. Clin. Med. 2018, 7(1), 5; https://doi.org/10.3390/jcm7010005

Association of Maternal Factors with Perinatal Complications in Pregnancies Complicated with Diabetes: A Single-Center Retrospective Analysis

1
Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan
2
Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160-8582, Japan
*
Author to whom correspondence should be addressed.
Received: 9 November 2017 / Revised: 16 December 2017 / Accepted: 19 December 2017 / Published: 2 January 2018
(This article belongs to the Special Issue Therapeutic Strategies for Diabetes in Pregnancy)
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Abstract

Objective: The aim of this study was to clarify the association of maternal factors with perinatal complications in pregnancies complicated with type 1 (T1D) or type 2 diabetes (T2D). Methods: We conducted a retrospective chart review and enrolled 26 Japanese pregnant women with diabetes who received perinatal care at our hospital between 2008 and 2015. Perinatal complications were defined as one or more of the following: miscarriage, fetal death, fetal dysfunction, fetal structural anomaly, small-for-gestational age, large-for-gestational age (LGA), premature birth, neonatal hypoglycemia, pregnancy-induced hypertension (PIH), deterioration of maternal kidney function, and urgent Caesarean section (CS). The associations between perinatal complications and maternal factors were examined. Results: Approximately 70% and 50% of women with T1D and T2D experienced perinatal complications, respectively. LGA, neonatal hypoglycemia, and urgent CS were major perinatal complications in women with T1D, while PIH and urgent CS were major complications in those with T2D. In women with T1D, pre-gestational HbA1c was significantly higher in women with perinatal complications than in those without. In women with T2D, pre-gestational body mass index was significantly higher in women with perinatal complications than in those without. Conclusions: These findings suggest that while pre-gestational glycemic control remains the most important issue in women with T1D, pre-gestational weight control in addition to glycemic control should be greater emphasized in women with T2D to reduce the risk of perinatal complications. View Full-Text
Keywords: pregnancy; type 1 diabetes; type 2 diabetes; perinatal complication pregnancy; type 1 diabetes; type 2 diabetes; perinatal complication
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Endo, S.; Saisho, Y.; Miyakoshi, K.; Ochiai, D.; Matsumoto, T.; Kawano, Y.; Mitsuishi, M.; Irie, J.; Tanaka, M.; Meguro, S.; Tanaka, M.; Itoh, H. Association of Maternal Factors with Perinatal Complications in Pregnancies Complicated with Diabetes: A Single-Center Retrospective Analysis. J. Clin. Med. 2018, 7, 5.

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