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J. Clin. Med. 2018, 7(1), 4; https://doi.org/10.3390/jcm7010004

Experimental Models of Irritable Bowel Syndrome and the Role of the Enteric Neurotransmission

Department of Experimental and Clinical Medicine, Research Unit of Histology and Embryology, University of Florence, Viale Pieraccini, 6-50139 Florence, Italy
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Received: 6 December 2017 / Revised: 14 December 2017 / Accepted: 18 December 2017 / Published: 3 January 2018
(This article belongs to the Special Issue Irritable Bowel Syndrome)
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Abstract

Irritable bowel syndrome (IBS) is one of the most common gastrointestinal diseases in humans. It is characterized by visceral pain and/or discomfort, hypersensitivity and abnormal motor responses along with change in gut habits. Although the etio-pathogenesis of IBS is only partially understood, a main role has been attributed to psychosocial stress of different origin. Animal models such as neonatal maternal separation, water avoidance stress and wrap restraint stress have been developed as psychosocial stressors in the attempt to reproduce the IBS symptomatology and identify the cellular mechanisms responsible for the disease. The study of these models has led to the production of drugs potentially useful for IBS treatment. This review intends to give an overview on the results obtained with the animal models; to emphasize the role of the enteric nervous system in IBS appearance and evolution and as a possible target of drug therapies. View Full-Text
Keywords: corticotropin releasing factor (CRF); irritable bowel syndrome (IBS); maternal separation (MS); neurotransmitters; pain; psychosocial stress; visceral hyperalgesia; water avoidance stress (WAS); wrap restrain stress (WRS) corticotropin releasing factor (CRF); irritable bowel syndrome (IBS); maternal separation (MS); neurotransmitters; pain; psychosocial stress; visceral hyperalgesia; water avoidance stress (WAS); wrap restrain stress (WRS)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Vannucchi, M.G.; Evangelista, S. Experimental Models of Irritable Bowel Syndrome and the Role of the Enteric Neurotransmission. J. Clin. Med. 2018, 7, 4.

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