Next Article in Journal
Gender and Weight Influence Quality of Life in Irritable Bowel Syndrome
Previous Article in Journal
Oxidative Stress: Mechanistic Insights into Inherited Mitochondrial Disorders and Parkinson’s Disease
Article Menu
Issue 11 (November) cover image

Export Article

Open AccessFeature PaperReview
J. Clin. Med. 2017, 6(11), 102; doi:10.3390/jcm6110102

Is Exaggerated Release of Arginine Vasopressin an Endocrine Disorder? Pathophysiology and Treatment

Department of Endocrinology and Metabolism, International University of Health and Welfare Hospital, Nasushiobara 329-2763, Tochigi, Japan
Received: 2 October 2017 / Revised: 27 October 2017 / Accepted: 30 October 2017 / Published: 31 October 2017
View Full-Text   |   Download PDF [595 KB, uploaded 1 November 2017]   |  

Abstract

Exaggerated release of arginine vasopressin (AVP) is profoundly involved in impaired water excretion and related hyponatremia. Such disorders underlie syndromes of inappropriate secretion of antidiuretic hormone (SIADH) and edematous diseases, such as congestive heart failure and decompensated liver cirrhosis. All the causes are fundamentally from non-endocrine diseases. AVP-induced water retention could produce hyponatremia, and further accelerate poor long-term outcome of edematous diseases. Administration of AVP V2 receptor antagonists verifies how much AVP is involved in the pathogenesis of the impaired water excretion. The present paper demonstrated that exaggerated release of AVP plays a crucial role as an accessory endocrine disorder in pathological states of water retention and dilutional hyponatremia in non-endocrine disorders. View Full-Text
Keywords: impaired water excretion; hyponatremia; aquaporin 2; arterial underfilling; heart failure; SIADH; vasopressin (AVP) V2 receptor antagonist impaired water excretion; hyponatremia; aquaporin 2; arterial underfilling; heart failure; SIADH; vasopressin (AVP) V2 receptor antagonist
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Ishikawa, S.-E. Is Exaggerated Release of Arginine Vasopressin an Endocrine Disorder? Pathophysiology and Treatment. J. Clin. Med. 2017, 6, 102.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top