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J. Clin. Med. 2016, 5(3), 33; doi:10.3390/jcm5030033

Acute Myeloid Leukemia: A Concise Review

1
Medical Oncology/Hematology, Department of Internal Medicine, Starling-Loving Hall, Room M365, 320 W. 10th Ave., Columbus, OH 43210, USA
2
Division of Hematology, Department of Internal Medicine, 460 W 12th Ave, Columbus, OH 43210, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Jeffrey E. Rubnitz
Received: 11 December 2015 / Revised: 1 February 2016 / Accepted: 29 February 2016 / Published: 5 March 2016
View Full-Text   |   Download PDF [246 KB, uploaded 5 March 2016]

Abstract

Acute myeloid leukemia (AML) is a heterogeneous clonal disorder characterized by immature myeloid cell proliferation and bone marrow failure. Cytogenetics and mutation testing remain a critical prognostic tool for post induction treatment. Despite rapid advances in the field including new drug targets and increased understanding of the biology, AML treatment remains unchanged for the past three decades with the majority of patients eventually relapsing and dying of the disease. Allogenic transplant remains the best chance for cure for patients with intermediate or high risk disease. In this review, we discuss the landmark genetic studies that have improved outcome prediction and novel therapies. View Full-Text
Keywords: AML; leukemia; review AML; leukemia; review
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Saultz, J.N.; Garzon, R. Acute Myeloid Leukemia: A Concise Review. J. Clin. Med. 2016, 5, 33.

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