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J. Clin. Med. 2016, 5(3), 31; doi:10.3390/jcm5030031

The Application of Genetic Risk Scores in Age-Related Macular Degeneration: A Review

1
Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA
2
Institute for Computational Biology, Case Western Reserve University, Cleveland, OH 44106, USA
3
Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94158, USA
4
John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
*
Authors to whom correspondence should be addressed.
Academic Editors: Lindsay Farrer and Margaret DeAngelis
Received: 1 December 2015 / Revised: 19 February 2016 / Accepted: 29 February 2016 / Published: 4 March 2016
(This article belongs to the Special Issue Age-Related Macular Disease)
View Full-Text   |   Download PDF [514 KB, uploaded 4 March 2016]   |  

Abstract

Age-related macular degeneration (AMD), a highly prevalent and impactful disease of aging, is inarguably influenced by complex interactions between genetic and environmental factors. Various risk scores have been tested that assess measurable genetic and environmental contributions to disease. We herein summarize and review the ability and utility of these numerous models for prediction of AMD and suggest additional risk factors to be incorporated into clinically useful predictive models of AMD. View Full-Text
Keywords: age-related macular degeneration (AMD); genetics; risk score age-related macular degeneration (AMD); genetics; risk score
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MDPI and ACS Style

Cooke Bailey, J.N.; Hoffman, J.D.; Sardell, R.J.; Scott, W.K.; Pericak-Vance, M.A.; Haines, J.L. The Application of Genetic Risk Scores in Age-Related Macular Degeneration: A Review. J. Clin. Med. 2016, 5, 31.

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