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J. Clin. Med. 2016, 5(3), 28; doi:10.3390/jcm5030028

Circulating miR-21 and miR-29a as Markers of Disease Severity and Etiology in Cholestatic Pediatric Liver Disease

1
Department of Paediatric Hepatology and Gastroenterology, Hannover Medical School, Carl-Neuberg-Strasse 1, Hannover 30625, Germany
2
Institute for Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Carl-Neuberg-Strasse 1, Hannover 30625, Germany
3
Integrated Research and Treatment Centre Transplantation (IFB-Tx), Hannover Medical School, Hannover 30625 Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Rajagopal N. Aravalli
Received: 19 November 2015 / Revised: 19 January 2016 / Accepted: 27 January 2016 / Published: 25 February 2016
(This article belongs to the Special Issue MicroRNAs: Novel Biomarkers for Liver Diseases)
View Full-Text   |   Download PDF [754 KB, uploaded 25 February 2016]   |  

Abstract

Circulating microRNAs have been investigated as markers of disease severity in a variety of conditions. We examined whether circulating miR-21 and miR-29a could serve as markers of hepatic fibrosis and disease etiology in children with various liver diseases. Circulating miR-21 and miR-29a were determined in 58 children (21 female, age 0.1–17.8 (median 9.8) years)) with chronic liver disease and compared to histological grading of hepatic fibrosis. 22 healthy children served as controls for circulating miRNAs. Levels of circulating miR-21 appeared to be age-dependent in healthy children. Children with biliary atresia had significantly higher levels of miR-21 compared both to healthy controls and to age-matched children with other cholestatic liver disease. Circulating miR-29a levels in biliary atresia children did not differ from healthy controls, but tended to be higher than in age-matched children with other cholestatic liver disease. Neither miR-21 nor miR-29a correlated well with hepatic fibrosis. Circulating miR-21 and miR-29a levels can potentially serve as non-invasive diagnostic markers to differentiate biliary atresia from other cholestatic disease in infancy. They do not appear suitable as non-invasive markers for the degree of hepatic fibrosis in an unselected cohort of children with various liver diseases. The discriminating effect regarding neonatal cholestasis should be followed up in a prospective longitudinal study. View Full-Text
Keywords: biliary atresia; hepatic fibrosis; microRNA; paediatrics biliary atresia; hepatic fibrosis; microRNA; paediatrics
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MDPI and ACS Style

Goldschmidt, I.; Thum, T.; Baumann, U. Circulating miR-21 and miR-29a as Markers of Disease Severity and Etiology in Cholestatic Pediatric Liver Disease. J. Clin. Med. 2016, 5, 28.

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