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J. Clin. Med. 2015, 4(9), 1688-1712; doi:10.3390/jcm4091688

MicroRNAs in the Cholangiopathies: Pathogenesis, Diagnosis, and Treatment

1
Division of Gastroenterology and Hepatology, and the Mayo Clinic Center for Signaling in Gastroenterology, Mayo Clinic, Rochester, MN 55905, USA
2
Department of Surgery, Mayo Clinic Rochester, MN 55905, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Rajagopal N. Aravalli
Received: 7 August 2015 / Revised: 7 August 2015 / Accepted: 11 August 2015 / Published: 26 August 2015
(This article belongs to the Special Issue MicroRNAs: Novel Biomarkers for Liver Diseases)
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Abstract

The cholangiopathies are a group of liver diseases resulting from different etiologies but with the cholangiocyte as the primary target. As a group, the cholangiopathies result in significant morbidity and mortality and represent one of the main indications for liver transplant in both children and adults. Contributing to this situation is the absence of a thorough understanding of their pathogenesis and a lack of adequate diagnostic and prognostic biomarkers. MicroRNAs are small non-coding RNAs that modify gene expression post-transcriptionally. They have been implicated in the pathogenesis of many diseases, including the cholangiopathies. Thus, in this review we provide an overview of the literature on miRNAs in the cholangiopathies and discuss future research directions. View Full-Text
Keywords: microRNA; cholangiopathies; cholangiocarcinoma microRNA; cholangiopathies; cholangiocarcinoma
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Pisarello, M.J.L.; Loarca, L.; Ivanics, T.; Morton, L.; LaRusso, N. MicroRNAs in the Cholangiopathies: Pathogenesis, Diagnosis, and Treatment. J. Clin. Med. 2015, 4, 1688-1712.

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