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J. Clin. Med. 2015, 4(9), 1668-1687; doi:10.3390/jcm4091668

Clinical Potential of microRNA-7 in Cancer

1
Laboratory for Cancer Medicine, Harry Perkins Institute of Medical Research, The University of Western Australia Centre for Medical Research, Perth, WA 6000, Australia
2
School of Medicine and Pharmacology, University of Western Australia, Nedlands, WA 6009, Australia
*
Author to whom correspondence should be addressed.
Academic Editors: Takahiro Ochiya and Ryou-u Takahashi
Received: 30 June 2015 / Revised: 17 August 2015 / Accepted: 17 August 2015 / Published: 25 August 2015
(This article belongs to the Special Issue MicroRNAs: Novel Biomarkers and Therapeutic Targets for Human Cancers)
View Full-Text   |   Download PDF [233 KB, uploaded 25 August 2015]   |  

Abstract

microRNAs (miRNAs) are a family of short, non-coding RNA molecules that drive a complex network of post-transcriptional gene regulation by enhancing target mRNA decay and/or inhibiting protein synthesis from mRNA transcripts. They regulate genes involved in key aspects of normal cell growth, development and the maintenance of body homeostasis and have been closely linked to the development and progression of human disease, in particular cancer. Over recent years there has been much interest regarding their potential as biomarkers and as therapeutic agents or targets. microRNA-7 (miR-7) is a 23 nucleotide (nt) miRNA known primarily to act as a tumour suppressor. miR-7 directly inhibits a number of oncogenic targets and impedes various aspects of cancer progression in vitro and in vivo, however, some studies have also implicated miR-7 in oncogenic roles. This review summarises the role of miR-7 in cancer, its potential in miRNA-based replacement therapy and its capacity as both a diagnostic and prognostic biomarker. View Full-Text
Keywords: microRNA-7; microRNA replacement therapy; biomarker; cancer; tumour suppressor microRNA-7; microRNA replacement therapy; biomarker; cancer; tumour suppressor
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Horsham, J.L.; Kalinowski, F.C.; Epis, M.R.; Ganda, C.; Brown, R.A.M.; Leedman, P.J. Clinical Potential of microRNA-7 in Cancer. J. Clin. Med. 2015, 4, 1668-1687.

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