Small Drusen and Age-Related Macular Degeneration: The Beaver Dam Eye Study
AbstractWe tested the hypothesis that large areas of small hard drusen (diameter <63 µm) and intermediate drusen (diameter 63–124 µm) are associated with the incidence of age-related macular degeneration (AMD). Eyes of 3344 older adults with at least two consecutive visits spaced five years apart over a 20-year period were included. A 6-level severity scale, including no drusen, four levels of increasing area (from minimal (<2596 µm²) to large (>9086 µm²)) of only small hard drusen, and intermediate drusen, was used. The five-year incidence of AMD was 3% in eyes at the start of the interval with no, minimal, small, and moderate areas of only small drusen and 5% and 25% for eyes with large area of only small drusen and intermediate drusen, respectively. Compared to eyes with a moderate area of small drusen, the odds ratio (OR) of developing AMD in eyes with a large area of only small drusen was 1.8 (p < 0.001). Compared to eyes with large area of only small drusen, eyes with intermediate drusen had an OR of 5.5 (p < 0.001) of developing AMD. Our results are consistent with our hypothesis that large areas of only small drusen are associated with the incidence of AMD. View Full-Text
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Klein, R.; Myers, C.E.; Lee, K.E.; Gangnon, R.E.; Sivakumaran, T.A.; Iyengar, S.K.; Klein, B.E.K. Small Drusen and Age-Related Macular Degeneration: The Beaver Dam Eye Study. J. Clin. Med. 2015, 4, 425-440.
Klein R, Myers CE, Lee KE, Gangnon RE, Sivakumaran TA, Iyengar SK, Klein BEK. Small Drusen and Age-Related Macular Degeneration: The Beaver Dam Eye Study. Journal of Clinical Medicine. 2015; 4(3):425-440.Chicago/Turabian Style
Klein, Ronald; Myers, Chelsea E.; Lee, Kristine E.; Gangnon, Ronald E.; Sivakumaran, Theru A.; Iyengar, Sudha K.; Klein, Barbara E.K. 2015. "Small Drusen and Age-Related Macular Degeneration: The Beaver Dam Eye Study." J. Clin. Med. 4, no. 3: 425-440.