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J. Clin. Med. 2015, 4(2), 204-230; doi:10.3390/jcm4020204

Recent Insights into the Control of Human Papillomavirus (HPV) Genome Stability, Loss, and Degradation

NanoVir, 4717 Campus, Kalamazoo, MI 49008, USA
Academic Editor: Christopher Downing
Received: 6 November 2014 / Revised: 5 December 2014 / Accepted: 18 December 2014 / Published: 27 January 2015
(This article belongs to the Special Issue Clinical Advances of Human Papillomaviruses)
View Full-Text   |   Download PDF [551 KB, uploaded 29 January 2015]   |  

Abstract

Most human papillomavirus (HPV) antiviral strategies have focused upon inhibiting viral DNA replication, but it is increasingly apparent that viral DNA levels can be chemically controlled by approaches that promote its instability. HPVs and other DNA viruses have a tenuous relationship with their hosts. They must replicate and hide from the DNA damage response (DDR) and innate immune systems, which serve to protect cells from foreign or "non-self" DNA, and yet they draft these same systems to support their life cycles. DNA binding antiviral agents promoting massive viral DNA instability and elimination are reviewed. Mechanistic studies of these agents have identified genetic antiviral enhancers and repressors, antiviral sensitizers, and host cell elements that protect and stabilize HPV genomes. Viral DNA degradation appears to be an important means of controlling HPV DNA levels in some cases, but the underlying mechanisms remain poorly understood. These findings may prove useful not only for understanding viral DNA persistence but also in devising future antiviral strategies. View Full-Text
Keywords: HPV; antiviral; polyamide; antiviral sensitizer; MRE11; viral persistence; TDP1; TDP2; RTEL1; RUVBL2 HPV; antiviral; polyamide; antiviral sensitizer; MRE11; viral persistence; TDP1; TDP2; RTEL1; RUVBL2
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Fisher, C. Recent Insights into the Control of Human Papillomavirus (HPV) Genome Stability, Loss, and Degradation. J. Clin. Med. 2015, 4, 204-230.

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