Next Article in Journal
Three Adult Cases of Orbital Hidrocystoma Presenting with Blepharoptosis
Next Article in Special Issue
Treatment of Acute Myeloid Leukemia in Adolescent and Young Adult Patients
Previous Article in Journal
Acknowledgement to Reviewers of the Journal of Clinical Medicine in 2014
Previous Article in Special Issue
Clinical Results of Hypomethylating Agents in AML Treatment
Article Menu

Export Article

Open AccessReview
J. Clin. Med. 2015, 4(1), 127-149; doi:10.3390/jcm4010127

Pediatric AML: From Biology to Clinical Management

Department of Pediatric Oncology, Erasmus MC-Sophia Children's Hospital, 3015CN Rotterdam, The Netherlands
*
Author to whom correspondence should be addressed.
Academic Editor: Celalettin Ustun
Received: 17 October 2014 / Accepted: 28 November 2014 / Published: 9 January 2015
(This article belongs to the Special Issue AML in the Molecular Age: From Biology to Clinical Management)
View Full-Text   |   Download PDF [971 KB, uploaded 12 January 2015]   |  

Abstract

Pediatric acute myeloid leukemia (AML) represents 15%–20% of all pediatric acute leukemias. Survival rates have increased over the past few decades to ~70%, due to improved supportive care, optimized risk stratification and intensified chemotherapy. In most children, AML presents as a de novo entity, but in a minority, it is a secondary malignancy. The diagnostic classification of pediatric AML includes a combination of morphology, cytochemistry, immunophenotyping and molecular genetics. Outcome is mainly dependent on the initial response to treatment and molecular and cytogenetic aberrations. Treatment consists of a combination of intensive anthracycline- and cytarabine-containing chemotherapy and stem cell transplantation in selected genetic high-risk cases or slow responders. In general, ~30% of all pediatric AML patients will suffer from relapse, whereas 5%–10% of the patients will die due to disease complications or the side-effects of the treatment. Targeted therapy may enhance anti-leukemic efficacy and minimize treatment-related morbidity and mortality, but requires detailed knowledge of the genetic abnormalities and aberrant pathways involved in leukemogenesis. These efforts towards future personalized therapy in a rare disease, such as pediatric AML, require intensive international collaboration in order to enhance the survival rates of pediatric AML, while aiming to reduce long-term toxicity. View Full-Text
Keywords: pediatric AML; clinical management; cytogenetics; molecular aberrations pediatric AML; clinical management; cytogenetics; molecular aberrations
Figures

Figure 1a

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

de Rooij, J.D.E.; Zwaan, C.M.; van den Heuvel-Eibrink, M. Pediatric AML: From Biology to Clinical Management. J. Clin. Med. 2015, 4, 127-149.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top