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J. Clin. Med. 2014, 3(2), 614-631; doi:10.3390/jcm3020614
Article

It’s More Than a Blood Test: Patients’ Perspectives on Noninvasive Prenatal Testing

1,2,3,* , 1,†
, 1,†
, 3,†
 and 2,†
1 Department of Bioethics, Cleveland Clinic, 9500 Euclid Avenue JJ60, Cleveland, OH 44195, USA 2 Department of Obstetrics and Gynecology, Cleveland Clinic Women's Health Institute, 9500 Euclid Avenue A81, Cleveland, OH 44195, USA 3 Genomic Medicine Institute, Cleveland Clinic Center for Personalized Genetic Healthcare, 9500 Euclid Avenue NE50, Cleveland, OH 44195, USA These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 5 April 2014 / Revised: 3 May 2014 / Accepted: 6 May 2014 / Published: 19 June 2014
(This article belongs to the Special Issue Prenatal Genetic Screening and Diagnosis-Part 2)
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Abstract

Noninvasive prenatal testing (NIPT) offers pregnant women a new risk assessment tool for fetal aneuploidy that is superior to conventional screening tests. We conducted focus groups with women who were currently pregnant or had recently delivered in the past year to characterize their perspectives about NIPT and to explore factors they would consider during decision making about its use. Women identified accuracy, early timing, testing ease, and determination of fetal sex as advantages of NIPT over other screens, and the noninvasive method of NIPT as an advantage over diagnostic tests. False positive and false negative results, anxiety, cost and insurance coverage were seen as disadvantages of NIPT. Women who do not want fetal aneuploidy information most likely will not undergo NIPT, despite its advantages over other screening tests. However, given its advantages, the decision to have NIPT is straightforward for women who want genetic information about the fetus. Women emphasized the need to make autonomous, private, and informed choices about NIPT, as they would with any prenatal genetic testing option. These perspectives may guide clinicians to conduct effective and clinically relevant counseling with pregnant women who consider utilizing this new genetic technology.
Keywords: noninvasive prenatal testing; patients’ perspectives; patient decision making noninvasive prenatal testing; patients’ perspectives; patient decision making
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Farrell, R.M.; Mercer, M.B.; Agatisa, P.K.; Smith, M.B.; Philipson, E. It’s More Than a Blood Test: Patients’ Perspectives on Noninvasive Prenatal Testing. J. Clin. Med. 2014, 3, 614-631.

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