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J. Clin. Med. 2014, 3(1), 323-333; doi:10.3390/jcm3010323

The Impacts of Obesity and Metabolic Abnormality on Carotid Intima-Media Thickness and Non-Alcoholic Fatty Liver Disease in Children from an Inland Chinese City

1
Departments of Endocrinology, the First People's Hospital, 39 Dongmaoling Road, Yueyang 414000, Hunan, China
2
Palmer Laboratory of Cell & Molecular Biology, PCCR, Palmer College of Chiropractic-Florida, 4705 S. Clyde Morris Blvd, Port Orange, FL 32129, USA
3
Departments of Ultrasound, the First People's Hospital, 39 Dongmaoling Road, Yueyang 414000, Hunan, China
*
Author to whom correspondence should be addressed.
Received: 9 January 2014 / Revised: 18 February 2014 / Accepted: 24 February 2014 / Published: 20 March 2014
(This article belongs to the Special Issue Obesity, Diabetes and Metabolic Syndrome)
View Full-Text   |   Download PDF [233 KB, uploaded 20 March 2014]

Abstract

The Chinese inland, where low child obesity and overweight rates were reported in earlier studies, has recently experienced rapid economy changes. This may impact children’s health. In the present study, we investigated the obesity rate, metabolic health status, and their impacts on carotid intima-media thickness (IMT) and non-alcoholic fatty liver disease (NAFLD) among children from Yueyang, an inland city of China. We found that the obesity rate was about 5% for both 7- and 11-year olds. Overweightness rates were 9.5% and 11.5% for the 7- and 11-year olds, respectively. Clinical and laboratory examinations revealed significant differences among different weight groups in the 11-year old volunteers, which were absent in the 7-year olds. Further statistical analysis showed that: age, BMI, blood pressure, triglyceride level, and metabolic abnormality were positively correlated to carotid IMT; triglyceride level, obesity, male, and the number of metabolic abnormalities were independent risk factors for NAFLD in these children. Our study suggests that: childhood overweightness and obesity are now epidemic in Yueyang, which have contributed to increased carotid IMT and may also increased NAFLD incidents; and serum triglyceride level is a critical factor in the development of childhood NAFLD. Thus, childhood metabolic health warrants further vigorous research in the inland of China. View Full-Text
Keywords: Yueyang; metabolic syndrome; carotid intima-media thickness; public health; non-alcoholic fatty liver disease Yueyang; metabolic syndrome; carotid intima-media thickness; public health; non-alcoholic fatty liver disease
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Wang, X.-Y.; Zhang, X.-H.; Yao, C.H.; Zhu, H.-H.; Zhang, L. The Impacts of Obesity and Metabolic Abnormality on Carotid Intima-Media Thickness and Non-Alcoholic Fatty Liver Disease in Children from an Inland Chinese City. J. Clin. Med. 2014, 3, 323-333.

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