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J. Clin. Med. 2014, 3(1), 144-152; doi:10.3390/jcm3010144
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Women’s Attitudes Regarding Prenatal Testing for a Range of Congenital Disorders of Varying Severity

1,2,* , 1
 and 1
Received: 27 December 2013; in revised form: 6 January 2014 / Accepted: 7 January 2014 / Published: 21 January 2014
(This article belongs to the Special Issue Prenatal Genetic Screening and Diagnosis-Part 2)
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Abstract: Little is known about women’s comparative attitudes towards prenatal testing for different categories of genetic disorders. We interviewed women who delivered healthy infants within the past year and assessed attitudes towards prenatal screening and diagnostic testing, as well as pregnancy termination, for Down syndrome (DS), fragile X (FraX), cystic fibrosis (CF), spinal muscular atrophy (SMA), phenylketonuria (PKU) and congenital heart defects (CHD). Ninety-five women aged 21 to 48 years participated, of whom 60% were Caucasian, 23% Asian, 10% Latina and 7% African American; 82% were college graduates. Ninety-five to ninety-eight percent indicated that they would have screening for each condition, and the majority would have amniocentesis (64% for PKU to 72% for SMA). Inclinations regarding pregnancy termination varied by condition: Whereas only 10% reported they would probably or definitely terminate a pregnancy for CHD, 41% indicated they would do so for DS and 62% for SMA. Most women in this cohort reported that they would undergo screening for all six conditions presented, the majority without the intent to terminate an affected pregnancy. These women were least inclined to terminate treatable disorders (PKU, CHD) versus those associated with intellectual disability (DS, FraX) and were most likely to terminate for SMA, typically lethal in childhood.
Keywords: prenatal genetic screening; fragile X syndrome; spinal muscular atrophy; abortion; prenatal diagnosis prenatal genetic screening; fragile X syndrome; spinal muscular atrophy; abortion; prenatal diagnosis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Norton, M.E.; Nakagawa, S.; Kuppermann, M. Women’s Attitudes Regarding Prenatal Testing for a Range of Congenital Disorders of Varying Severity. J. Clin. Med. 2014, 3, 144-152.

AMA Style

Norton ME, Nakagawa S, Kuppermann M. Women’s Attitudes Regarding Prenatal Testing for a Range of Congenital Disorders of Varying Severity. Journal of Clinical Medicine. 2014; 3(1):144-152.

Chicago/Turabian Style

Norton, Mary E.; Nakagawa, Sanae; Kuppermann, Miriam. 2014. "Women’s Attitudes Regarding Prenatal Testing for a Range of Congenital Disorders of Varying Severity." J. Clin. Med. 3, no. 1: 144-152.

J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert