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Membranes 2016, 6(3), 43; doi:10.3390/membranes6030043

Protein-Based Graphene Biosensors: Optimizing Artificial Chemoreception in Bilayer Lipid Membranes

Laboratory of Simulation of Industrial Processes, Department of Industrial Management and Technology, School of Maritime and Industry, University of Piraeus, Piraeus 18534, Greece
Laboratory of Inorganic & Analytical Chemistry, School of Chemical Engineering, Department of Chemical Sciences, National Technical University of Athens, Athens 15780, Greece
Laboratory of Environmental Chemistry, Department of Chemistry, University of Athens, Athens 15771, Greece
Author to whom correspondence should be addressed.
Academic Editor: Bernhard Schuster
Received: 19 July 2016 / Revised: 2 September 2016 / Accepted: 5 September 2016 / Published: 7 September 2016
(This article belongs to the Special Issue Supported Lipid Membranes)
View Full-Text   |   Download PDF [1562 KB, uploaded 7 September 2016]   |  


Proteinaceous moieties are critical elements in most detection systems, including biosensing platforms. Their potential is undoubtedly vast, yet many issues regarding their full exploitation remain unsolved. On the other hand, the biosensor formats with the higher marketability probabilities are enzyme in nature and electrochemical in concept. To no surprise, alternative materials for hosting catalysis within an electrode casing have received much attention lately to demonstrate a catalysis-coated device. Graphene and ZnO are presented as ideal materials to modify electrodes and biosensor platforms, especially in protein-based detection. Our group developed electrochemical sensors based on these nanomaterials for the sensitive detection of cholesterol using cholesterol oxidase incorporated in stabilized lipid films. A comparison between the two platforms is provided and discussed. In a broader sense, the not-so-remote prospect of quickly assembling a protein-based flexible biosensing detector to fulfill site-specific requirements is appealing to both university researchers and industry developers. View Full-Text
Keywords: biosensors; electrochemistry; graphene nanosheets; ZnO nanowalls; stabilized lipid films; cholesterol oxidase biosensors; electrochemistry; graphene nanosheets; ZnO nanowalls; stabilized lipid films; cholesterol oxidase

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Siontorou, C.G.; Georgopoulos, K.N.; Nikoleli, G.-P.; Nikolelis, D.P.; Karapetis, S.K.; Bratakou, S. Protein-Based Graphene Biosensors: Optimizing Artificial Chemoreception in Bilayer Lipid Membranes. Membranes 2016, 6, 43.

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