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Membranes 2015, 5(1), 84-98; doi:10.3390/membranes5010084

The Road not Taken: Less Traveled Roads from the TGN to the Plasma Membrane

Biozentrum: Growth & Development, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland
Academic Editor: Morten S. Nielsen
Received: 3 October 2014 / Accepted: 27 February 2015 / Published: 10 March 2015
(This article belongs to the Special Issue Trafficking of Membrane Receptors 2015)
View Full-Text   |   Download PDF [605 KB, uploaded 10 March 2015]   |  

Abstract

The trans-Golgi network functions in the distribution of cargo into different transport vesicles that are destined to endosomes, lysosomes and the plasma membrane. Over the years, it has become clear that more than one transport pathway promotes plasma membrane localization of proteins. In spite of the importance of temporal and spatial control of protein localization at the plasma membrane, the regulation of sorting into and the formation of different transport containers are still poorly understood. In this review different transport pathways, with a special emphasis on exomer-dependent transport, and concepts of regulation and sorting at the TGN are discussed. View Full-Text
Keywords: membrane transport; vesicle transport; trans-Golgi network; exocytosis; secretion; adaptor complex; small GTPase membrane transport; vesicle transport; trans-Golgi network; exocytosis; secretion; adaptor complex; small GTPase
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Spang, A. The Road not Taken: Less Traveled Roads from the TGN to the Plasma Membrane. Membranes 2015, 5, 84-98.

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