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Vaccines 2018, 6(3), 58; https://doi.org/10.3390/vaccines6030058

The Future of Influenza Vaccines: A Historical and Clinical Perspective

1
Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
2
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
Received: 7 July 2018 / Revised: 21 August 2018 / Accepted: 27 August 2018 / Published: 30 August 2018
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Abstract

For centuries, the development of vaccines to prevent infectious disease was an empirical process. From smallpox variolation in Song dynasty China, through the polysaccharide capsule vaccines developed in the 1970s, vaccines were made either from the pathogen itself, treated in some way to render it attenuated or non-infectious, or from a closely related non-pathogenic strain. In recent decades, new scientific knowledge and technologies have enabled rational vaccine design in a way that was unimaginable before. However, vaccines optimal against some infectious diseases, influenza among them, have remained elusive. This review will highlight the challenges that influenza viruses pose for rational vaccine design. In particular, it will consider the clinically beneficial endpoints, beyond complete sterilizing immunity, that have been achieved with vaccines against other infectious diseases, as well as the barriers to achieving similar success against influenza. View Full-Text
Keywords: influenza; vaccine; transmission; morbidity; mortality; efficacy; effectiveness influenza; vaccine; transmission; morbidity; mortality; efficacy; effectiveness
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Bouvier, N.M. The Future of Influenza Vaccines: A Historical and Clinical Perspective. Vaccines 2018, 6, 58.

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