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Vaccines 2016, 4(2), 18; doi:10.3390/vaccines4020018

Mitochondrion: A Promising Target for Nanoparticle-Based Vaccine Delivery Systems

1
NanoTherapeutics Research Laboratory, Department of Chemistry, University of Georgia, Athens, GA 30602, USA
2
School of Medicine, Department of Pulmonary and Critical Care, University of Virginia, Charlottesville, WV 22908, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Diane M. Harper
Received: 8 February 2016 / Revised: 31 March 2016 / Accepted: 8 April 2016 / Published: 1 June 2016
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Abstract

Vaccination is one of the most popular technologies in disease prevention and eradication. It is promising to improve immunization efficiency by using vectors and/or adjuvant delivery systems. Nanoparticle (NP)-based delivery systems have attracted increasing interest due to enhancement of antigen uptake via prevention of vaccine degradation in the biological environment and the intrinsic immune-stimulatory properties of the materials. Mitochondria play paramount roles in cell life and death and are promising targets for vaccine delivery systems to effectively induce immune responses. In this review, we focus on NPs-based delivery systems with surfaces that can be manipulated by using mitochondria targeting moieties for intervention in health and disease. View Full-Text
Keywords: vaccine; mitochondria targeting; nanoparticles; antigen delivery vaccine; mitochondria targeting; nanoparticles; antigen delivery
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Wen, R.; Umeano, A.C.; Francis, L.; Sharma, N.; Tundup, S.; Dhar, S. Mitochondrion: A Promising Target for Nanoparticle-Based Vaccine Delivery Systems. Vaccines 2016, 4, 18.

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