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Vaccines 2016, 4(2), 10; doi:10.3390/vaccines4020010

Burkholderia cepacia Complex Vaccines: Where Do We Go from here?

1
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA
2
Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX 77555, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Diane M. Harper
Received: 28 January 2016 / Revised: 7 April 2016 / Accepted: 8 April 2016 / Published: 15 April 2016
View Full-Text   |   Download PDF [482 KB, uploaded 15 April 2016]   |  

Abstract

Burkholderia comprises a wide variety of environmental Gram-negative bacteria. Burkholderia cepacia complex (Bcc) includes several Burkholderia species that pose a health hazard as they are able to cause respiratory infections in patients with chronic granulomatous disease and cystic fibrosis. Due to the intrinsic resistance to a wide array of antibiotics and naturally occurring immune evasion strategies, treatment of Bcc infections often proves to be unsuccessful. To date, limited work related to vaccine development has been performed for Bcc pathogens. In this review, we have gathered key aspects of Bcc research that have been reported in recent years related to vaccine efforts, virulence, immune responses, and animal models, and use this information to inform the research community of areas of opportunity toward development of a viable Bcc vaccine. View Full-Text
Keywords: Burkholderia cepacia complex; vaccine; cystic fibrosis Burkholderia cepacia complex; vaccine; cystic fibrosis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Pradenas, G.A.; Ross, B.N.; Torres, A.G. Burkholderia cepacia Complex Vaccines: Where Do We Go from here? Vaccines 2016, 4, 10.

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