Vaccines 2013, 1(3), 328-342; doi:10.3390/vaccines1030328
Review

Isotype Diversification of IgG Antibodies to HIV Gag Proteins as a Therapeutic Vaccination Strategy for HIV Infection

1 School of Pathology and Laboratory Medicine, University of Western Australia, Perth 6009, Australia 2 Department of Clinical Immunology, Royal Perth Hospital and PathWest Laboratory Medicine, Perth 6000, Australia
* Author to whom correspondence should be addressed.
Received: 5 June 2013; in revised form: 11 July 2013 / Accepted: 23 July 2013 / Published: 9 August 2013
(This article belongs to the Special Issue HIV Vaccines)
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Abstract: The development of vaccines to treat and prevent human immunodeficiency virus (HIV) infection has been hampered by an incomplete understanding of “protective” immune responses against HIV. Natural control of HIV-1 infection is associated with T-cell responses against HIV-1 Gag proteins, particularly CD8+ T-cell responses restricted by “protective” HLA-B alleles, but other immune responses also contribute to immune control. These immune responses appear to include IgG antibodies to HIV-1 Gag proteins, interferon-a-dependant natural killer (NK) cell responses and plasmacytoid dendritic cell (pDC) responses. Here, it is proposed that isotype diversification of IgG antibodies against HIV-1 Gag proteins, to include IgG2, as well as IgG3 and IgG1 antibodies, will broaden the function of the antibody response and facilitate accessory cell responses against HIV-1 by NK cells and pDCs. We suggest that this should be investigated as a vaccination strategy for HIV-1 infection.
Keywords: HIV; vaccine; HIV-1 Gag; IgG antibody diversification; IgG subclasses

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MDPI and ACS Style

French, M.A.; Abudulai, L.N.; Fernandez, S. Isotype Diversification of IgG Antibodies to HIV Gag Proteins as a Therapeutic Vaccination Strategy for HIV Infection. Vaccines 2013, 1, 328-342.

AMA Style

French MA, Abudulai LN, Fernandez S. Isotype Diversification of IgG Antibodies to HIV Gag Proteins as a Therapeutic Vaccination Strategy for HIV Infection. Vaccines. 2013; 1(3):328-342.

Chicago/Turabian Style

French, Martyn A.; Abudulai, Laila N.; Fernandez, Sonia. 2013. "Isotype Diversification of IgG Antibodies to HIV Gag Proteins as a Therapeutic Vaccination Strategy for HIV Infection." Vaccines 1, no. 3: 328-342.

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