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Antioxidants 2017, 6(2), 33; doi:10.3390/antiox6020033

The Interplay between Oncogenic Signaling Networks and Mitochondrial Dynamics

Department of Microbiology, Immunology and Cancer Biology, University of Virginia Health System, Charlottesville, VA 22908, USA
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Author to whom correspondence should be addressed.
Academic Editor: Yisang Yoon
Received: 4 March 2017 / Revised: 10 May 2017 / Accepted: 12 May 2017 / Published: 17 May 2017
(This article belongs to the Special Issue Mitochondrial Shape Change in Physio-Pathology)
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Abstract

Mitochondria are dynamic organelles that alter their organization in response to a variety of cellular cues. Mitochondria are central in many biologic processes, such as cellular bioenergetics and apoptosis, and mitochondrial network morphology can contribute to those physiologic processes. Some of the biologic processes that are in part governed by mitochondria are also commonly deregulated in cancers. Furthermore, patient tumor samples from a variety of cancers have revealed that mitochondrial dynamics machinery may be deregulated in tumors. In this review, we will discuss how commonly mutated oncogenes and their downstream effector pathways regulate the mitochondrial dynamics machinery to promote changes in mitochondrial morphology as well as the physiologic consequences of altered mitochondrial morphology for tumorigenic growth. View Full-Text
Keywords: mitochondrial dynamics; oncogenic signaling; cancer mitochondrial dynamics; oncogenic signaling; cancer
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Nagdas, S.; Kashatus, D.F. The Interplay between Oncogenic Signaling Networks and Mitochondrial Dynamics. Antioxidants 2017, 6, 33.

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