Next Article in Journal
Abnormalities of Mitochondrial Dynamics in Neurodegenerative Diseases
Previous Article in Journal
Antioxidant Properties of Selenophene, Thiophene and Their Aminocarbonitrile Derivatives
Previous Article in Special Issue
The Role of Copper Chaperone Atox1 in Coupling Redox Homeostasis to Intracellular Copper Distribution
Article Menu
Issue 2 (June) cover image

Export Article

Open AccessReview
Antioxidants 2017, 6(2), 24; doi:10.3390/antiox6020024

Zinc and Oxidative Stress: Current Mechanisms

Department of Nutrition, Federal University of Piauí, Campus Minister Petrônio Portela, Teresina 64049-550, Brazil
*
Author to whom correspondence should be addressed.
Academic Editors: Ananda S. Prasad and Bin Bao
Received: 30 September 2016 / Revised: 15 March 2017 / Accepted: 23 March 2017 / Published: 29 March 2017
(This article belongs to the Special Issue Oxidative Stress and Metals Metabolism)
View Full-Text   |   Download PDF [509 KB, uploaded 29 March 2017]   |  

Abstract

Oxidative stress is a metabolic dysfunction that favors the oxidation of biomolecules, contributing to the oxidative damage of cells and tissues. This consequently contributes to the development of several chronic diseases. In particular, zinc is one of the most relevant minerals to human health, because of its antioxidant properties. This review aims to provide updated information about the mechanisms involved in the protective role of zinc against oxidative stress. Zinc acts as a co-factor for important enzymes involved in the proper functioning of the antioxidant defense system. In addition, zinc protects cells against oxidative damage, acts in the stabilization of membranes and inhibits the enzyme nicotinamide adenine dinucleotide phosphate oxidase (NADPH-Oxidase). Zinc also induces the synthesis of metallothioneins, which are proteins effective in reducing hydroxyl radicals and sequestering reactive oxygen species (ROS) produced in stressful situations, such as in type 2 diabetes, obesity and cancer. Literature provides strong evidence for the role of zinc in the protection against oxidative stress in several diseases. View Full-Text
Keywords: zinc; oxidative stress; mechanisms zinc; oxidative stress; mechanisms
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Marreiro, D.N.; Cruz, K.J.C.; Morais, J.B.S.; Beserra, J.B.; Severo, J.S.; de Oliveira, A.R.S. Zinc and Oxidative Stress: Current Mechanisms. Antioxidants 2017, 6, 24.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Antioxidants EISSN 2076-3921 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top