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Antioxidants 2017, 6(2), 22; doi:10.3390/antiox6020022

Antioxidant Properties of Selenophene, Thiophene and Their Aminocarbonitrile Derivatives

Aram Bagrat Nalbandyan Institute of Chemical Physics, National Academy of Sciences, 5/2 Sevak Street, Yerevan 0014, Armenia
Author to whom correspondence should be addressed.
Academic Editors: Xin Gen Lei and Wen-Hsing Cheng
Received: 10 January 2017 / Revised: 10 March 2017 / Accepted: 12 March 2017 / Published: 24 March 2017
(This article belongs to the Special Issue Selenium and Selenoproteins for Optimal Health)
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The oxygen radical absorbance capacity (ORAC) method was used to detect the antiperoxyradical ability of organoselenium compounds: selenophene and its derivative, 2-amino-4,5,6,7-tetrahydro-1-selenophene-3-carbonitrile (ATSe); while as a comparison, the sulfur-containing analogue of selenophene—thiophene and its derivative—2-amino-4,5,6,7-tetrahydro-1-thiophene-3-carbonitrile (ATS)—was selected. Cyclic voltammetry (CV), differential pulse voltammetry (DPV) and squarewave voltammetry (SWV) methods were used to determine the redox characteristics of organoselenium and organosulfur compounds. The antiradical activity and capacity of the studied compounds were also measured by using stable radical 2,2ʹ-diphenyl-1-picrylhydrazyl (DPPH). Detected anodic peaks of the oxidation of selenophene, thiophene and their derivatives in CV, DPV and SWV in the interval of −1200 ÷ (+1600) mV potentials in regard to the Ag/Ag+ medium of acetonitrile prove the presence of antiperoxyradical activity in regard to oxidizers, i.e., peroxyradicals. The chemical mechanism of the antiperoxyradical ability of selenophene, thiophene and their organic derivatives is proposed. View Full-Text
Keywords: selenophene; thiophene; aminocarbonitrile derivatives; antioxidant; antiperoxyradical capacity; CV; DPV and SWV voltammetry selenophene; thiophene; aminocarbonitrile derivatives; antioxidant; antiperoxyradical capacity; CV; DPV and SWV voltammetry

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Tavadyan, L.A.; Manukyan, Z.H.; Harutyunyan, L.H.; Musayelyan, M.V.; Sahakyan, A.D.; Tonikyan, H.G. Antioxidant Properties of Selenophene, Thiophene and Their Aminocarbonitrile Derivatives. Antioxidants 2017, 6, 22.

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