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Antioxidants 2016, 5(3), 24; doi:10.3390/antiox5030024

Beyond Diabetes: Does Obesity-Induced Oxidative Stress Drive the Aging Process?

1
Geriatric Research, Education and Clinical Center, South Texas Veterans Health Care System, San Antonio, TX 78245, USA
2
The Sam and Ann Barshop Institute for Longevity and Aging Studies, Department of Molecular Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78245, USA
Academic Editor: Stanley Omaye
Received: 22 June 2016 / Revised: 6 July 2016 / Accepted: 12 July 2016 / Published: 18 July 2016
(This article belongs to the Special Issue Oxidative Stress and Aging: Past, Present and Future Concepts)
View Full-Text   |   Download PDF [235 KB, uploaded 18 July 2016]   |  

Abstract

Despite numerous correlative data, a causative role for oxidative stress in mammalian longevity has remained elusive. However, there is strong evidence that increased oxidative stress is associated with exacerbation of many diseases and pathologies that are also strongly related to advanced age. Obesity, or increased fat accumulation, is one of the most common chronic conditions worldwide and is associated with not only metabolic dysfunction but also increased levels of oxidative stress in vivo. Moreover, obesity is also associated with significantly increased risks of cardiovascular disease, neurological decline and cancer among many other diseases as well as a significantly increased risk of mortality. In this review, we investigate the possible interpretation that the increased incidence of these diseases in obesity may be due to chronic oxidative stress mediating segmental acceleration of the aging process. Understanding how obesity can alter cellular physiology beyond that directly related to metabolic function could open new therapeutic areas of approach to extend the period of healthy aging among people of all body composition. View Full-Text
Keywords: reactive oxygen species; mitochondria; inflammation; adipose; fatty acid oxidation; longevity; health span reactive oxygen species; mitochondria; inflammation; adipose; fatty acid oxidation; longevity; health span
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Salmon, A.B. Beyond Diabetes: Does Obesity-Induced Oxidative Stress Drive the Aging Process? Antioxidants 2016, 5, 24.

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