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Antioxidants 2016, 5(2), 14; doi:10.3390/antiox5020014

Development of Antioxidant COX-2 Inhibitors as Radioprotective Agents for Radiation Therapy—A Hypothesis-Driven Review

1
Department of Radiopharmaceutical and Chemical Biology, Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Bautzner Landstrasse 400, Dresden D-01328, Germany
2
Department of Chemistry and Food Chemistry, Technische Universität Dresden, Dresden D-01062, Germany
*
Authors to whom correspondence should be addressed.
Academic Editor: Alexandros G. Georgakilas
Received: 15 March 2016 / Revised: 8 April 2016 / Accepted: 11 April 2016 / Published: 19 April 2016
View Full-Text   |   Download PDF [1839 KB, uploaded 19 April 2016]   |  

Abstract

Radiation therapy (RT) evolved to be a primary treatment modality for cancer patients. Unfortunately, the cure or relief of symptoms is still accompanied by radiation-induced side effects with severe acute and late pathophysiological consequences. Inhibitors of cyclooxygenase-2 (COX-2) are potentially useful in this regard because radioprotection of normal tissue and/or radiosensitizing effects on tumor tissue have been described for several compounds of this structurally diverse class. This review aims to substantiate the hypothesis that antioxidant COX-2 inhibitors are promising radioprotectants because of intercepting radiation-induced oxidative stress and inflammation in normal tissue, especially the vascular system. For this, literature reporting on COX inhibitors exerting radioprotective and/or radiosensitizing action as well as on antioxidant COX inhibitors will be reviewed comprehensively with the aim to find cross-points of both and, by that, stimulate further research in the field of radioprotective agents. View Full-Text
Keywords: COX-2 inhibitors (COXIBs); cyclooxygenases; normal tissue; nonsteroidal anti-inflammatory drugs (NSAIDS); oxidative stress; radiation-induced vascular dysfunction; radioprotection; radiosensitization; reactive oxygen/nitrogen species; tumor models COX-2 inhibitors (COXIBs); cyclooxygenases; normal tissue; nonsteroidal anti-inflammatory drugs (NSAIDS); oxidative stress; radiation-induced vascular dysfunction; radioprotection; radiosensitization; reactive oxygen/nitrogen species; tumor models
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Laube, M.; Kniess, T.; Pietzsch, J. Development of Antioxidant COX-2 Inhibitors as Radioprotective Agents for Radiation Therapy—A Hypothesis-Driven Review. Antioxidants 2016, 5, 14.

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