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Antioxidants 2015, 4(2), 293-303; doi:10.3390/antiox4020293

A Review of the Use of Topical Calendula in the Prevention and Treatment of Radiotherapy-Induced Skin Reactions

1
Miller School of Medicine, University of Miami, 1600 Northwest 10th Avenue, Miami, FL 33136, USA
2
Department of Medical Education, Macneal Hospital, 3231 South Euclid Avenue, Suite 203 Berwyn, IL 60402, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Alexandros G. Georgakilas
Received: 10 February 2015 / Revised: 16 April 2015 / Accepted: 16 April 2015 / Published: 23 April 2015
View Full-Text   |   Download PDF [369 KB, uploaded 23 April 2015]

Abstract

Calendula is a topical agent derived from a plant of the marigold family Calendula Officinalis. Containing numerous polyphenolic antioxidants, calendula has been studied in both the laboratory and clinical setting for the use in treating and preventing radiation induced skin toxicity. Despite strong evidence in the laboratory supporting calendula’s mechanism of action in preventing radiation induced skin toxicity, clinical studies have demonstrated mixed results. In light of the controversy surrounding the efficacy of calendula in treating and preventing radiodermatitis, the topic warrants further discussion. View Full-Text
Keywords: radiation induced skin toxicity; calendula; complementary and alternative medicine; radiodermatitis; radiation induced dermatitis; cancer radiation induced skin toxicity; calendula; complementary and alternative medicine; radiodermatitis; radiation induced dermatitis; cancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kodiyan, J.; Amber, K.T. A Review of the Use of Topical Calendula in the Prevention and Treatment of Radiotherapy-Induced Skin Reactions. Antioxidants 2015, 4, 293-303.

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