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Antioxidants 2015, 4(2), 322-344; doi:10.3390/antiox4020322

Oxidative Stress and Dietary Fat Type in Relation to Periodontal Disease

1
Institute of Nutrition and Food Technology "José Mataix Verdú", Biomedical Research Center (CIBM), University of Granada, Avda. del Conocimiento s.n., Armilla, Granada 18100, Spain
2
Department of Periodontology, Dental School, University of Sevilla, C/Avicena s.n., Sevilla 41009, Spain
3
Department of Clinical Sciences, Marche Polytechnic University, Ancona 60100, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Maurizio Battino
Received: 4 March 2015 / Revised: 17 April 2015 / Accepted: 20 April 2015 / Published: 28 April 2015
(This article belongs to the Special Issue Antioxidants and Periodontal Diseases)
View Full-Text   |   Download PDF [795 KB, uploaded 28 April 2015]

Abstract

Oxidative stress is one of the main factors studied to explain the pathophysiological mechanisms of inflammatory conditions, such as periodontitis. In this respect, nutrition may be of great importance. Actually, research on nutrients’ effects on periodontal diseases has expanded to include those influencing the redox status, which correlates to the inflammatory process. Dietary fat or lipids are often blamed as the major source of excess energy. Consequently, when caloric intake exceeds energy expenditure, the resultant substrate-induced increase in citric acid cycle activity generates an excess of reactive oxygen species (ROS). In addition, dietary fatty acid intake influences in relative fatty acid composition of biological membranes determining its susceptibility to oxidative alterations. From this standpoint, here, we reviewed studies analyzing the dietary fat role in periodontal disease. Research data suggest that periodontal health could be achieved by main dietary strategies which include substitution of saturated fats with monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA), particularly n-3 PUFA. Maybe in the future, we should analyze the diet and provide some advice to periodontitis patients to improve treatment outcomes. View Full-Text
Keywords: periodontitis; lipids; fatty acids; cholesterol; diet; dietary fats; nutrition periodontitis; lipids; fatty acids; cholesterol; diet; dietary fats; nutrition
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Varela-López, A.; Quiles, J.L.; Cordero, M.; Giampieri, F.; Bullón, P. Oxidative Stress and Dietary Fat Type in Relation to Periodontal Disease. Antioxidants 2015, 4, 322-344.

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