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Challenges for MicroRNA Microarray Data Analysis
Microarrays 2013, 2(2), 63-80; doi:10.3390/microarrays2020063

Phenotypic MicroRNA Microarrays

Institut Pasteur Korea, IP-Korea, 696 Sampyeong-dong, Bundang-gu, Seongnam-si, Gyeonggi-do 463-400, Korea
* Author to whom correspondence should be addressed.
Received: 8 February 2013 / Revised: 20 March 2013 / Accepted: 25 March 2013 / Published: 3 April 2013
(This article belongs to the Special Issue MicroRNA Microarrays)
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Microarray technology has become a very popular approach in cases where multiple experiments need to be conducted repeatedly or done with a variety of samples. In our lab, we are applying our high density spots microarray approach to microscopy visualization of the effects of transiently introduced siRNA or cDNA on cellular morphology or phenotype. In this publication, we are discussing the possibility of using this micro-scale high throughput process to study the role of microRNAs in the biology of selected cellular models. After reverse-transfection of microRNAs and siRNA, the cellular phenotype generated by microRNAs regulated NF-κB expression comparably to the siRNA. The ability to print microRNA molecules for reverse transfection into cells is opening up the wide horizon for the phenotypic high content screening of microRNA libraries using cellular disease models.
Keywords: microRNA; siRNA; phenotypic screen microRNA; siRNA; phenotypic screen
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Kwon, Y.-J.; Heo, J.Y.; Kim, H.C.; Kim, J.Y.; Liuzzi, M.; Soloveva, V. Phenotypic MicroRNA Microarrays. Microarrays 2013, 2, 63-80.

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