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Brain Sci. 2017, 7(7), 74; doi:10.3390/brainsci7070074

Hypermethylation of Synphilin-1, Alpha-Synuclein-Interacting Protein (SNCAIP) Gene in the Cerebral Cortex of Patients with Sporadic Parkinson’s Disease

1
Department of Neurology/Movement Disorders, School of Medicine, Faculty of Medical Offices, 11370 Anderson, Suite B-100, Loma Linda, CA 92354, USA
2
School of Pharmacy, Loma Linda University, Loma Linda, CA 92354, USA
3
Center for Genomics & Department of Basic Sciences, School of Medicine, Loma Linda University, Loma Linda, CA 92354, USA
4
Department of Neurology, Mayo Clinic College of Medicine, Scottsdale, AZ 85255, USA
5
Banner Sun Health Research Institute, Sun City, AZ 85351, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Steven J. Frucht and Pichet Termsarasab
Received: 20 May 2017 / Revised: 22 June 2017 / Accepted: 23 June 2017 / Published: 27 June 2017
(This article belongs to the Special Issue Pathophysiology and Genetics of Movement Disorders)
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Abstract

Objective: To determine and compare DNA methylation patterns between patients with Parkinson’s disease (PD) and age- and sex-similar matched non-PD controls. Background: Epigenetic regulation is one of the major mechanisms for an organism to respond to the environment through changes in gene expression and has been implicated in numerous disease processes. We would like to examine epigenetic modification patterns that may predispose or protect against PD. Methods: Frozen tissue samples of the human cerebral cortex from 12 PD patients and 12 subjects without PD pathology were obtained. Genome-wide DNA methylation profiling was performed using the Illumina HumanMethylation450 BeadChip array. Differential methylation was defined as a mean methylation level difference (delta β) of at least 0.20 (Δβ ≥ 0.20). Methylation regions with an absolute delta β value ≥ 0.20 were selected for further gene function studies. Results: We identified 2795 differentially methylated CpG sites in the frontal cortex of PD cases with a detection p-value of ≤ 0.01 and 328 differentially methylated CpG sites with a detection p-value of ≤ 0.001. A pattern of robust hypermethylation of synphilin-1, α-synuclein-interacting protein (SNCAIP) gene was found in the brain of PD cases (p = 4.93 × 10−7 and delta β = 0.60). Conclusion: Our findings support a link between SNCAIP methylation and PD risk. Hypomethylation of SNCAIP may function to protect against PD. The current results may suggest that the methylation status of SNCAIP could be useful as a marker in PD diagnosis and treatment and warrants further investigation. View Full-Text
Keywords: epigenetics; DNA methylation; Parkinson’s disease; genetics; SNCAIP; synphilin-1 epigenetics; DNA methylation; Parkinson’s disease; genetics; SNCAIP; synphilin-1
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MDPI and ACS Style

Dashtipour, K.; Tafreshi, A.; Adler, C.; Beach, T.; Chen, X.; Serrano, G.; Tashiro, S.; Wang, C. Hypermethylation of Synphilin-1, Alpha-Synuclein-Interacting Protein (SNCAIP) Gene in the Cerebral Cortex of Patients with Sporadic Parkinson’s Disease. Brain Sci. 2017, 7, 74.

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