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Brain Sci. 2017, 7(6), 69; doi:10.3390/brainsci7060069

Contribution of the Degeneration of the Neuro-Axonal Unit to the Pathogenesis of Multiple Sclerosis

1
Department of Anatomy and Cell Biology, CMSNRC (Cameco MS Neuroscience Research Center), University of Saskatchewan, Saskatoon, SK S7N0Z1, Canada
2
Veterans Administration Medical Center, Memphis, TN 38104, USA
3
Department of Neurology, University of Tennessee Health Science Center, Memphis, TN 38104, USA
4
Department of Neurology, University of Saskatchewan, Saskatoon, SK S7N0Z1, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Evanthia Bernitsas
Received: 5 May 2017 / Revised: 9 June 2017 / Accepted: 14 June 2017 / Published: 18 June 2017
(This article belongs to the Special Issue Pathophysiology and Imaging Diagnosis of Demyelinating Disorders)
View Full-Text   |   Download PDF [596 KB, uploaded 18 June 2017]   |  

Abstract

Multiple sclerosis (MS) is a demyelinating, autoimmune disease of the central nervous system. In recent years, it has become more evident that neurodegeneration, including neuronal damage and axonal injury, underlies permanent disability in MS. This manuscript reviews some of the mechanisms that could be responsible for neurodegeneration and axonal damage in MS and highlights the potential role that dysfunctional heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and antibodies to hnRNP A1 may play in MS pathogenesis. View Full-Text
Keywords: multiple sclerosis; RNA binding protein; neurodegeneration; axonal damage; hnRNP A1 multiple sclerosis; RNA binding protein; neurodegeneration; axonal damage; hnRNP A1
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Salapa, H.E.; Lee, S.; Shin, Y.; Levin, M.C. Contribution of the Degeneration of the Neuro-Axonal Unit to the Pathogenesis of Multiple Sclerosis. Brain Sci. 2017, 7, 69.

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