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Brain Sci. 2017, 7(3), 24; doi:10.3390/brainsci7030024

Genes, Gender, Environment, and Novel Functions of Estrogen Receptor Beta in the Susceptibility to Neurodevelopmental Disorders

Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge 14183, Sweden
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Author to whom correspondence should be addressed.
Academic Editor: Yu Ping Tang
Received: 17 October 2016 / Revised: 14 February 2017 / Accepted: 17 February 2017 / Published: 23 February 2017
(This article belongs to the Special Issue Sex Differences in Brain Development)
View Full-Text   |   Download PDF [433 KB, uploaded 23 February 2017]   |  

Abstract

Many neurological disorders affect men and women differently regarding prevalence, progression, and severity. It is clear that many of these disorders may originate from defective signaling during fetal or perinatal brain development, which may affect males and females differently. Such sex-specific differences may originate from chromosomal or sex-hormone specific effects. This short review will focus on the estrogen receptor beta (ERβ) signaling during perinatal brain development and put it in the context of sex-specific differences in neurodevelopmental disorders. We will discuss ERβ’s recent discovery in directing DNA de-methylation to specific sites, of which one such site may bear consequences for the susceptibility to the neurological reading disorder dyslexia. We will also discuss how dysregulations in sex-hormone signaling, like those evoked by endocrine disruptive chemicals, may affect this and other neurodevelopmental disorders in a sex-specific manner through ERβ. View Full-Text
Keywords: estrogen; testosterone; dyslexia; aromatase; brain; neurodevelopment; sex-difference; hormone; BPA; epigenetics estrogen; testosterone; dyslexia; aromatase; brain; neurodevelopment; sex-difference; hormone; BPA; epigenetics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Varshney, M.; Nalvarte, I. Genes, Gender, Environment, and Novel Functions of Estrogen Receptor Beta in the Susceptibility to Neurodevelopmental Disorders. Brain Sci. 2017, 7, 24.

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