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Brain Sci. 2016, 6(4), 48; doi:10.3390/brainsci6040048

Vocal Tremor: Novel Therapeutic Target for Deep Brain Stimulation

Department of Neurosurgery, Stanford University, 300 Pasteur Dr., Edwards Bldg. R-293, Stanford, CA 94305, USA
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Academic Editors: Tipu Aziz and Alex Green
Received: 27 July 2016 / Revised: 29 September 2016 / Accepted: 3 October 2016 / Published: 10 October 2016
(This article belongs to the Special Issue Deep Brain Stimulation (DBS) Applications)
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Abstract

Tremulous voice is characteristically associated with essential tremor, and is referred to as essential vocal tremor (EVT). Current estimates suggest that up to 40% of individuals diagnosed with essential tremor also present with EVT, which is associated with an impaired quality of life. Traditional EVT treatments have demonstrated limited success in long-term management of symptoms. However, voice tremor has been noted to decrease in patients receiving deep brain stimulation (DBS) with the targeting of thalamic nuclei. In this study, we describe our multidisciplinary procedure for awake, frameless DBS with optimal stimulation targets as well as acoustic analysis and laryngoscopic assessment to quantify tremor reduction. Finally, we investigate the most recent clinical evidence regarding the procedure. View Full-Text
Keywords: deep brain stimulation; awake DBS; ventral intermediate nucleus; VIM; dysphonia; essential tremor; essential vocal tremor; EVT; voice; tremulous voice; laryngoscopy; acoustic analysis; microelectrode recording deep brain stimulation; awake DBS; ventral intermediate nucleus; VIM; dysphonia; essential tremor; essential vocal tremor; EVT; voice; tremulous voice; laryngoscopy; acoustic analysis; microelectrode recording
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ravikumar, V.K.; Ho, A.L.; Parker, J.J.; Erickson-DiRenzo, E.; Halpern, C.H. Vocal Tremor: Novel Therapeutic Target for Deep Brain Stimulation. Brain Sci. 2016, 6, 48.

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