Next Article in Journal
The Sound of Vision Project: On the Feasibility of an Audio-Haptic Representation of the Environment, for the Visually Impaired
Next Article in Special Issue
Oligodendrocyte Injury and Pathogenesis of HIV-1-Associated Neurocognitive Disorders
Previous Article in Journal / Special Issue
Neuroimmunology of the Interleukins 13 and 4
Article Menu

Export Article

Open AccessFeature PaperReview
Brain Sci. 2016, 6(2), 19; doi:10.3390/brainsci6020019

Impact of Increased Astrocyte Expression of IL-6, CCL2 or CXCL10 in Transgenic Mice on Hippocampal Synaptic Function

Molecular and Cellular Neuroscience Department, The Scripps Research Institute, La Jolla, CA 92037, USA
Academic Editor: Balapal S. Basavarajappa
Received: 17 May 2016 / Revised: 8 June 2016 / Accepted: 13 June 2016 / Published: 17 June 2016
(This article belongs to the Special Issue Advances in Neuroimmunology)
View Full-Text   |   Download PDF [2015 KB, uploaded 17 June 2016]   |  

Abstract

An important aspect of CNS disease and injury is the elevated expression of neuroimmune factors. These factors are thought to contribute to processes ranging from recovery and repair to pathology. The complexity of the CNS and the multitude of neuroimmune factors that are expressed in the CNS during disease and injury is a challenge to an understanding of the consequences of the elevated expression relative to CNS function. One approach to address this issue is the use of transgenic mice that express elevated levels of a specific neuroimmune factor in the CNS by a cell type that normally produces it. This approach can provide basic information about the actions of specific neuroimmune factors and can contribute to an understanding of more complex conditions when multiple neuroimmune factors are expressed. This review summarizes studies using transgenic mice that express elevated levels of IL-6, CCL2 or CXCL10 through increased astrocyte expression. The studies focus on the effects of these neuroimmune factors on synaptic function at the Schaffer collateral to CA1 pyramidal neuron synapse of the hippocampus, a brain region that plays a key role in cognitive function. View Full-Text
Keywords: pyramidal neurons; Schaffer collaterals; LTP; neuroimmune; alcohol; field potential recordings; cytokine; chemokine pyramidal neurons; Schaffer collaterals; LTP; neuroimmune; alcohol; field potential recordings; cytokine; chemokine
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Gruol, D.L. Impact of Increased Astrocyte Expression of IL-6, CCL2 or CXCL10 in Transgenic Mice on Hippocampal Synaptic Function. Brain Sci. 2016, 6, 19.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Brain Sci. EISSN 2076-3425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top