Next Article in Journal
The Human Factors and Ergonomics of P300-Based Brain-Computer Interfaces
Previous Article in Journal
Nonmechanical Roles of Dystrophin and Associated Proteins in Exercise, Neuromuscular Junctions, and Brains
Article Menu

Export Article

Open AccessArticle
Brain Sci. 2015, 5(3), 299-317; doi:10.3390/brainsci5030299

Identification and Characterization of GABAergic Projection Neurons from Ventral Hippocampus to Amygdala

1
Institute of Anatomy, Otto-von-Guericke University, Leipziger Str. 44, D-39120 Magdeburg, Germany
2
Institute of Biometry and Medical Informatics, Otto-von-Guericke University, Leipziger Str. 44, D-39120 Magdeburg, Germany
3
Clinic of Neurology, Otto-von-Guericke University, Leipziger Str. 44, D-39120 Magdeburg, Germany
4
Institute of Biology, Department of Genetics and Molecular Neurobiology, Otto-von-Guericke University, Leipziger Str. 44, D-39120 Magdeburg, Germany
5
Center of Behavioral Brain Science, D-39120 Magdeburg, Germany
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Bruno Meloni
Received: 29 June 2015 / Revised: 23 July 2015 / Accepted: 24 July 2015 / Published: 31 July 2015
View Full-Text   |   Download PDF [3498 KB, uploaded 31 July 2015]   |  

Abstract

GABAergic local circuit neurons are critical for the network activity and functional interaction of the amygdala and hippocampus. Previously, we obtained evidence for a GABAergic contribution to the hippocampal projection into the basolateral amygdala. Using fluorogold retrograde labeling, we now demonstrate that this projection indeed has a prominent GABAergic component comprising 17% of the GABAergic neurons in the ventral hippocampus. A majority of the identified GABAergic projection neurons are located in the stratum oriens of area CA1, but cells are also found in the stratum pyramidale and stratum radiatum. We could detect the expression of different markers of interneuron subpopulations, including parvalbumin and calbindin, somatostatin, neuropeptide Y, and cholecystokinin in such retrogradely labeled GABA neurons. Thus GABAergic projection neurons to the amygdala comprise a neurochemically heterogeneous group of cells from different interneuron populations, well situated to control network activity patterns in the amygdalo-hippocampal system. View Full-Text
Keywords: fear; memory; GABAergic; hippocampus; amygdala fear; memory; GABAergic; hippocampus; amygdala
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Lübkemann, R.; Eberhardt, J.; Röhl, F.-W.; Janitzky, K.; Nullmeier, S.; Stork, O.; Schwegler, H.; Linke, R. Identification and Characterization of GABAergic Projection Neurons from Ventral Hippocampus to Amygdala. Brain Sci. 2015, 5, 299-317.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Brain Sci. EISSN 2076-3425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top