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Brain Sci. 2015, 5(2), 188-200; doi:10.3390/brainsci5020188

Association Study between the CD157/BST1 Gene and Autism Spectrum Disorders in a Japanese Population

1
Research Center for Child Mental Development, Kanazawa University, Kanazawa 920-8640, Japan
2
MEXT Strategic Research Program for Brain Sciences (SRPBS), Okazaki 444-0840, Japan
3
Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8641, Japan
4
Medical Education Research Center, Kanazawa University Graduate School of Medical Science, Kanazawa 920-8640, Japan
*
Author to whom correspondence should be addressed.
Academic Editors: Susan Shur-Fen Gau and Xiaoming Wang
Received: 10 November 2014 / Revised: 4 May 2015 / Accepted: 11 May 2015 / Published: 20 May 2015
(This article belongs to the Special Issue Autism Spectrum Disorder)
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Abstract

CD157, also referred to as bone marrow stromal cell antigen-1 (BST-1), is a glycosylphosphatidylinositol-anchored molecule that promotes pre-B-cell growth. Previous studies have reported associations between single-nucleotide polymorphisms (SNPs) of the CD157/BST1 gene with Parkinson’s disease. In an attempt to determine whether SNPs or haplotypes in the CD157/BST1 are associated with other brain disorders, we performed a case-control study including 147 autism spectrum disorder (ASD) patients at Kanazawa University Hospital in Japan and 150 unselected Japanese volunteers by the sequence-specific primer-polymerase chain reaction method combined with fluorescence correlation spectroscopy. Of 93 SNPs examined, two SNPs showed significantly higher allele frequencies in cases with ASDs than in unaffected controls (rs4301112, OR = 6.4, 95% CI = 1.9 to 22, p = 0.0007; and rs28532698, OR = 6.2, 95% CI = 1.8 to 21, p = 0.0012; Fisher’s exact test; p < 0.002 was considered significant after multiple testing correction). In addition, CT genotype in rs10001565 was more frequently observed in the ASD group than in the control group (OR = 15, 95% CI = 2.0 to 117, p = 0.0007; Fisher’s exact test). The present data indicate that genetic variation of the CD157/BST1 gene might confer susceptibility to ASDs. View Full-Text
Keywords: autism spectrum disorder; BST-1; CD157; single-nucleotide polymorphism autism spectrum disorder; BST-1; CD157; single-nucleotide polymorphism
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Yokoyama, S.; Al Mahmuda, N.; Munesue, T.; Hayashi, K.; Yagi, K.; Yamagishi, M.; Higashida, H. Association Study between the CD157/BST1 Gene and Autism Spectrum Disorders in a Japanese Population. Brain Sci. 2015, 5, 188-200.

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