Brain Sci. 2013, 3(3), 1182-1197; doi:10.3390/brainsci3031182

Repair of the Peripheral Nerve—Remyelination that Works

1,* email and 2email
Received: 24 June 2013; in revised form: 7 July 2013 / Accepted: 19 July 2013 / Published: 2 August 2013
(This article belongs to the Special Issue Myelin Repair)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: In this review we summarize the events known to occur after an injury in the peripheral nervous system. We have focused on the Schwann cells, as they are the most important cells for the repair process and facilitate axonal outgrowth. The environment created by this cell type is essential for the outcome of the repair process. The review starts with a description of the current state of knowledge about the initial events after injury, followed by Wallerian degeneration, and subsequent regeneration. The importance of surgical repair, carried out as soon as possible to increase the chances of a good outcome, is emphasized throughout the review. The review concludes by describing the target re-innervation, which today is one of the most serious problems for nerve regeneration. It is clear, compiling this data, that even though regeneration of the peripheral nervous system is possible, more research in this area is needed in order to perfect the outcome.
Keywords: peripheral nerve injury; Schwann cell; proliferation; bands of Büngner; nerve regeneration; myelination; target innervation; nerve repair
PDF Full-text Download PDF Full-Text [603 KB, uploaded 2 August 2013 09:14 CEST]

Export to BibTeX |

MDPI and ACS Style

Svennigsen, Å.F.; Dahlin, L.B. Repair of the Peripheral Nerve—Remyelination that Works. Brain Sci. 2013, 3, 1182-1197.

AMA Style

Svennigsen ÅF, Dahlin LB. Repair of the Peripheral Nerve—Remyelination that Works. Brain Sciences. 2013; 3(3):1182-1197.

Chicago/Turabian Style

Svennigsen, Åsa F.; Dahlin, Lars B. 2013. "Repair of the Peripheral Nerve—Remyelination that Works." Brain Sci. 3, no. 3: 1182-1197.

Brain Sci. EISSN 2076-3425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert