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Brain Sci. 2013, 3(2), 781-789; doi:10.3390/brainsci3020781
Article

Neurovascular Coupling of the Posterior Cerebral Artery in Spinal Cord Injury: A Pilot Study

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Received: 19 February 2013; in revised form: 26 April 2013 / Accepted: 29 April 2013 / Published: 8 May 2013
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Abstract: Purpose: To compare neurovascular coupling in the posterior cerebral artery (PCA) between those with spinal cord injury (SCI) and able bodied (AB) individuals. Methods: A total of seven SCI and seven AB were matched for age and sex. Measures included PCA velocity (PCAv), beat-by-beat blood pressure and end-tidal carbon dioxide. Posterior cerebral cortex activation was achieved by 10 cycles of (1) 30 s eyes closed (pre-stimulation), (2) 30 s reading (stimulation). Results: Blood pressure was significantly reduced in those with SCI (SBP: 100 ± 13 mmHg; DBP: 58 ± 13 mmHg) vs. AB (SBP: 121 ± 12 mmHg; DBP: 74 ± 9 mmHg) during both pre-stimulation and stimulation, but the relative increase was similar during the stimulation period. Changes in PCAv during stimulation were mitigated in the SCI group (6% ± 6%) vs. AB (29% ± 12%, P < 0.001). Heart rate and end-tidal carbon dioxide responded similarly between groups. Conclusions: Clearly, NVC is impaired in those with SCI. This study may provide a link between poor perfusion of the posterior cerebral region (containing the medullary autonomic centres) and autonomic dysfunction after SCI.
Keywords: spinal cord injury; neurovascular coupling; posterior cerebral artery spinal cord injury; neurovascular coupling; posterior cerebral artery
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Phillips, A.A.; Krassioukov, A.V.; Zheng, M.M.Z.; Warburton, D.E.R. Neurovascular Coupling of the Posterior Cerebral Artery in Spinal Cord Injury: A Pilot Study. Brain Sci. 2013, 3, 781-789.

AMA Style

Phillips AA, Krassioukov AV, Zheng MMZ, Warburton DER. Neurovascular Coupling of the Posterior Cerebral Artery in Spinal Cord Injury: A Pilot Study. Brain Sciences. 2013; 3(2):781-789.

Chicago/Turabian Style

Phillips, Aaron A.; Krassioukov, Andrei V.; Zheng, Mei M.Z.; Warburton, Darren E.R. 2013. "Neurovascular Coupling of the Posterior Cerebral Artery in Spinal Cord Injury: A Pilot Study." Brain Sci. 3, no. 2: 781-789.



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