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Aging, Aerobic Activity and Interhemispheric Communication
Atlanta Rehabilitation Research and Development Center of Excellence, Department of Veteran's Affairs, Decatur, GA 30033, USA
Department of Neurology, Emory University, Decatur, GA 30033, USA
Department of Veteran's Affairs Brain Rehabilitation and Research Center, Gainesville, FL 32609, USA
Department of Neurology, University of Florida, Gainesville, FL 32611, USA
Department of Physical Therapy, University of Florida, Gainesville, FL 32611, USA
Department of Aging and Geriatric Research, University of Florida, Gainesville, FL 32611, USA
Department of Physical Therapy, Georgia State University, Atlanta, GA 30303, USA
* Author to whom correspondence should be addressed.
Received: 27 September 2012; in revised form: 2 November 2012 / Accepted: 13 November 2012 / Published: 16 November 2012
Abstract: Recent studies have shown that during unimanual motor tasks, aging adults show bilateral recruitment of primary motor cortex (M1), while younger adults show a suppression of the ipsilateral motor cortex. Additional work has indicated that increased bilateral M1 recruitment in older adults may be deleterious when performing some motor tasks. However, higher levels of physical fitness are associated with improved dexterity and fitness may mitigate the loss of both inhibitory and excitatory communication in aging adults. The goal of this study was to assess dexterity and interhemispheric motor communication in physically fit and sedentary middle-age (40–60 years) right handed participants using tests of hand deftness and transcranial magnetic stimulation (TMS). To behaviorally assess the influence of interhemispheric communication on motor performance, participants also perform the coin rotation deftness task while maintaining pinch force with the opposite hand (bimanual condition). We correlated these behavioral measures with the ipsilateral silent period using TMS to assess interhemispheric inhibition. Our results show that the middle-aged adults who were physically fit had better dexterity of their right hand (finger tapping and peg-board). When performing the coin rotation task the fit group had no between hand differences, but the sedentary group’s left hand performance was inferior to the their right hand. We found that better dexterity correlated with ipsilateral silent period duration (greater inhibition) thereby supporting the postulate that fitness improves interhemispheric motor communication.
Keywords: aging; physical fitness; interhemispheric communication; transcranial magnetic stimulation; dexterity
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McGregor, K.M.; Heilman, K.M.; Nocera, J.R.; Patten, C.; Manini, T.M.; Crosson, B.; Butler, A.J. Aging, Aerobic Activity and Interhemispheric Communication. Brain Sci. 2012, 2, 634-648.
McGregor KM, Heilman KM, Nocera JR, Patten C, Manini TM, Crosson B, Butler AJ. Aging, Aerobic Activity and Interhemispheric Communication. Brain Sciences. 2012; 2(4):634-648.
McGregor, Keith M.; Heilman, Kenneth M.; Nocera, Joe R.; Patten, Carolynn; Manini, Todd M.; Crosson, Bruce; Butler, Andrew J. 2012. "Aging, Aerobic Activity and Interhemispheric Communication." Brain Sci. 2, no. 4: 634-648.