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Appl. Sci. 2018, 8(8), 1288; https://doi.org/10.3390/app8081288

Volumetric, Radiographic, and Histologic Analyses of Demineralized Dentin Matrix Combined with Recombinant Human Bone Morphogenetic Protein-2 for Ridge Preservation: A Prospective Randomized Controlled Trial in Comparison with Xenograft

1
Department of Periodontology, Korea University Anam Hospital, Seoul KS013, Korea
2
Department of Oral and Maxillofacial Surgery, Korea University Anam Hospital, Seoul KS013, Korea
3
R&D Department, Korea Tooth Bank, Seoul KS013, Korea
4
Department of Prosthodontics, Korea University Anam Hospital, Seoul KS013, Korea
These two authors contribute equally to this study, so they are co first authors.
*
Author to whom correspondence should be addressed.
Received: 21 June 2018 / Revised: 26 July 2018 / Accepted: 30 July 2018 / Published: 2 August 2018
(This article belongs to the Special Issue Development of Membranes for Oral and Maxillofacial Application)
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Abstract

The aim of this study was to evaluate the clinical, volumetric, radiographic, and histologic aspects of autogenous demineralized dentin matrix (DDM) combined with recombinant human bone morphogenetic protein-2 (rhBMP-2) used for ridge preservation, compared to those of deproteinized bovine bone with collagen (DBBC). Following atraumatic extraction, the socket was filled with DBBC, DDM, or rhBMP-2/DDM. Scanned images of dental casts and cone beam computed tomographs (CBCT) were superimposed for the calculation of soft and hard tissue volume alteration. Preoperative and postoperative measurements of the height and width of the alveolar ridge were compared using CBCT images. After 4 months, bone specimens were harvested for histomorphometric assessment. Loss of hard and soft tissue volume occurred at 4 months after extraction and ridge preservation in all groups. No volumetric differences were detected among the three groups before and 4 months after ridge preservation. The reduction in the horizontal width at 5 mm was higher in the DBBC compared to the DDM. Histologically, approximately 40% newly formed bone was founded in rhBMP-2/DDM group. The autogenous dentin matrix used to fill the socket was as beneficial for ridge preservation as conventional xenografts. The combination of rhBMP-2 with dentin matrix also demonstrated appreciable volumetric stability and higher new bone formation compared to DDM alone and DBBC. View Full-Text
Keywords: autografts; bone regeneration; bone morphogenetic proteins; bone substitutes; cone-beam computed tomography; tooth extraction autografts; bone regeneration; bone morphogenetic proteins; bone substitutes; cone-beam computed tomography; tooth extraction
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Jung, G.-U.; Jeon, T.-H.; Kang, M.-H.; Um, I.-W.; Song, I.-S.; Ryu, J.-J.; Jun, S.-H. Volumetric, Radiographic, and Histologic Analyses of Demineralized Dentin Matrix Combined with Recombinant Human Bone Morphogenetic Protein-2 for Ridge Preservation: A Prospective Randomized Controlled Trial in Comparison with Xenograft. Appl. Sci. 2018, 8, 1288.

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