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Appl. Sci. 2018, 8(8), 1287; https://doi.org/10.3390/app8081287

Demonstration of Subretinal Injection Using Common-Path Swept Source OCT Guided Microinjector

Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21218, USA
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Received: 28 June 2018 / Revised: 31 July 2018 / Accepted: 1 August 2018 / Published: 2 August 2018
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Abstract

In this paper, we present the development of a handheld common-path swept source optical coherence tomography (CP-SSOCT) guided microinjector system and demonstrated its utility by precisely injecting fluorescein dye in the subretinal layer of ex vivo bovine eyes. The system enables precise subretinal injection with micron-level injection depth control. This was achieved by using a high-resolution CP-SSOCT distal sensor and signal processing using a graphics-processing unit (GPU), which made a real-time smart motion control algorithm possible. The microinjector performance was first evaluated using a gelatin phantom in terms of its ability for dynamic depth targeting and injection depth. This is followed by using an ex vivo bovine eye model to perform multiple consecutive subretinal injections of fluorescein dye. The results validated the OCT guided injector’s ability to precisely guide and lock in the needle tip to the target depth during injection. The ex vivo evaluation tests demonstrate that an OCT-guided injector can consistently guide the injecting needle to the desired depth and is able to maintain the position with 9.38 μm average root mean square error during the injections. View Full-Text
Keywords: optical coherence tomography; surgical technology; optical coherence sensor; ophthalmology; robotic surgery optical coherence tomography; surgical technology; optical coherence sensor; ophthalmology; robotic surgery
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Kang, J.U.; Cheon, G.W. Demonstration of Subretinal Injection Using Common-Path Swept Source OCT Guided Microinjector. Appl. Sci. 2018, 8, 1287.

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